Co Trimoxazole and Glibenclamide: Drug Interaction Guide

Quick answer: This combination requires caution. Co Trimoxazole and Glibenclamide can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Co Trimoxazole interacts with Glibenclamide

Sulfamethoxazole inhibits CYP2C9-mediated metabolism of glibenclamide, increasing sulfonylurea exposure and the risk of prolonged hypoglycemia.

What you should do

Consider another antibiotic. If used together, increase glucose monitoring and reduce or temporarily withhold glibenclamide when appropriate.

Key facts

Severity

Moderate — caution required

Mechanism

Sulfamethoxazole inhibits CYP2C9-mediated metabolism of glibenclamide, increasing sulfonylurea exposure and the risk of ...

Action

Consider another antibiotic. If used together, increase glucose monitoring and reduce or temporarily withhold glibenclam...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Co Trimoxazole and Glibenclamide together?

With caution. Consider another antibiotic. If used together, increase glucose monitoring and reduce or temporarily withhold glibenclamide when appropriate.

What is the severity of this interaction?

The interaction between Co Trimoxazole and Glibenclamide is classified as Moderate — caution required. Sulfamethoxazole inhibits CYP2C9-mediated metabolism of glibenclamide, increasing sulfonylurea exposure and the risk of prolonged hypoglycemia.

What should I do if I'm prescribed both?

Consider another antibiotic. If used together, increase glucose monitoring and reduce or temporarily withhold glibenclamide when appropriate. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.