Fluconazole and Glibenclamide: Drug Interaction Guide

Quick answer: This combination requires caution. Fluconazole and Glibenclamide can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Fluconazole interacts with Glibenclamide

Fluconazole inhibits CYP2C9, reducing metabolism of glibenclamide and increasing the risk of prolonged hypoglycaemia.

What you should do

Monitor blood glucose closely and consider reducing the sulfonylurea dose during and shortly after fluconazole treatment.

Key facts

Severity

Moderate — caution required

Mechanism

Fluconazole inhibits CYP2C9, reducing metabolism of glibenclamide and increasing the risk of prolonged hypoglycaemia.

Action

Monitor blood glucose closely and consider reducing the sulfonylurea dose during and shortly after fluconazole treatment...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Fluconazole and Glibenclamide together?

With caution. Monitor blood glucose closely and consider reducing the sulfonylurea dose during and shortly after fluconazole treatment.

What is the severity of this interaction?

The interaction between Fluconazole and Glibenclamide is classified as Moderate — caution required. Fluconazole inhibits CYP2C9, reducing metabolism of glibenclamide and increasing the risk of prolonged hypoglycaemia.

What should I do if I'm prescribed both?

Monitor blood glucose closely and consider reducing the sulfonylurea dose during and shortly after fluconazole treatment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.