Clarithromycin and Palbociclib: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Clarithromycin and Palbociclib unless specifically directed by your doctor.
How Clarithromycin interacts with Palbociclib
Clarithromycin strongly inhibits CYP3A4, the principal pathway for palbociclib metabolism, increasing palbociclib exposure and toxicity.
What you should do
Avoid clarithromycin and use a non-CYP3A4-inhibiting alternative. If unavoidable, interrupt or reduce palbociclib according to its prescribing information.
Key facts
Severity
Major — avoid combination
Mechanism
Clarithromycin strongly inhibits CYP3A4, the principal pathway for palbociclib metabolism, increasing palbociclib exposu...
Action
Avoid clarithromycin and use a non-CYP3A4-inhibiting alternative. If unavoidable, interrupt or reduce palbociclib accord...
Frequently asked questions
Can I take Clarithromycin and Palbociclib together?
No — this combination should generally be avoided. Avoid clarithromycin and use a non-CYP3A4-inhibiting alternative. If unavoidable, interrupt or reduce palbociclib according to its prescribing information.
What is the severity of this interaction?
The interaction between Clarithromycin and Palbociclib is classified as Major — avoid combination. Clarithromycin strongly inhibits CYP3A4, the principal pathway for palbociclib metabolism, increasing palbociclib exposure and toxicity.
What should I do if I'm prescribed both?
Avoid clarithromycin and use a non-CYP3A4-inhibiting alternative. If unavoidable, interrupt or reduce palbociclib according to its prescribing information. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.