Clarithromycin and Olaparib: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Clarithromycin and Olaparib unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Clarithromycin interacts with Olaparib

Clarithromycin strongly inhibits CYP3A4, the principal pathway responsible for olaparib metabolism, thereby substantially increasing olaparib exposure.

What you should do

Avoid the combination and use an alternative antibiotic. If unavoidable, reduce olaparib according to its product-specific prescribing guidance.

Key facts

Severity

Major — avoid combination

Mechanism

Clarithromycin strongly inhibits CYP3A4, the principal pathway responsible for olaparib metabolism, thereby substantiall...

Action

Avoid the combination and use an alternative antibiotic. If unavoidable, reduce olaparib according to its product-specif...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Clarithromycin and Olaparib together?

No — this combination should generally be avoided. Avoid the combination and use an alternative antibiotic. If unavoidable, reduce olaparib according to its product-specific prescribing guidance.

What is the severity of this interaction?

The interaction between Clarithromycin and Olaparib is classified as Major — avoid combination. Clarithromycin strongly inhibits CYP3A4, the principal pathway responsible for olaparib metabolism, thereby substantially increasing olaparib exposure.

What should I do if I'm prescribed both?

Avoid the combination and use an alternative antibiotic. If unavoidable, reduce olaparib according to its product-specific prescribing guidance. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.