Olaparib and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Olaparib and Rifampicin unless specifically directed by your doctor.
How Olaparib interacts with Rifampicin
Rifampicin strongly induces CYP3A4, markedly reducing olaparib exposure and potentially compromising antitumour efficacy.
What you should do
Avoid concurrent use. Choose a non-inducing anti-infective or an alternative cancer treatment in consultation with the oncology team.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin strongly induces CYP3A4, markedly reducing olaparib exposure and potentially compromising antitumour efficacy...
Action
Avoid concurrent use. Choose a non-inducing anti-infective or an alternative cancer treatment in consultation with the o...
Frequently asked questions
Can I take Olaparib and Rifampicin together?
No — this combination should generally be avoided. Avoid concurrent use. Choose a non-inducing anti-infective or an alternative cancer treatment in consultation with the oncology team.
What is the severity of this interaction?
The interaction between Olaparib and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces CYP3A4, markedly reducing olaparib exposure and potentially compromising antitumour efficacy.
What should I do if I'm prescribed both?
Avoid concurrent use. Choose a non-inducing anti-infective or an alternative cancer treatment in consultation with the oncology team. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.