Clarithromycin and Cyclosporine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Clarithromycin and Cyclosporine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Clarithromycin interacts with Cyclosporine

Clarithromycin inhibits CYP3A4 and P-glycoprotein, reducing cyclosporine metabolism and transport. Cyclosporine concentrations may rise, increasing nephrotoxicity, hypertension, and neurotoxicity risk.

What you should do

Avoid if possible and use an alternative antibiotic. If unavoidable, reduce cyclosporine dose and monitor trough levels and renal function closely.

Key facts

Severity

Major — avoid combination

Mechanism

Clarithromycin inhibits CYP3A4 and P-glycoprotein, reducing cyclosporine metabolism and transport. Cyclosporine concentr...

Action

Avoid if possible and use an alternative antibiotic. If unavoidable, reduce cyclosporine dose and monitor trough levels ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Clarithromycin and Cyclosporine together?

No — this combination should generally be avoided. Avoid if possible and use an alternative antibiotic. If unavoidable, reduce cyclosporine dose and monitor trough levels and renal function closely.

What is the severity of this interaction?

The interaction between Clarithromycin and Cyclosporine is classified as Major — avoid combination. Clarithromycin inhibits CYP3A4 and P-glycoprotein, reducing cyclosporine metabolism and transport. Cyclosporine concentrations may rise, increasing nephrotoxicity, hypertension, and neurotoxicity risk.

What should I do if I'm prescribed both?

Avoid if possible and use an alternative antibiotic. If unavoidable, reduce cyclosporine dose and monitor trough levels and renal function closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.