Bosentan and Cyclosporine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Bosentan and Cyclosporine unless specifically directed by your doctor.
How Bosentan interacts with Cyclosporine
Cyclosporine inhibits hepatic uptake and CYP3A4-mediated clearance of bosentan, markedly increasing bosentan exposure. Bosentan can also induce CYP3A4 and reduce cyclosporine concentrations.
What you should do
Do not coadminister. Choose an alternative pulmonary hypertension treatment or immunosuppressant.
Key facts
Severity
Major — avoid combination
Mechanism
Cyclosporine inhibits hepatic uptake and CYP3A4-mediated clearance of bosentan, markedly increasing bosentan exposure. B...
Action
Do not coadminister. Choose an alternative pulmonary hypertension treatment or immunosuppressant.
Frequently asked questions
Can I take Bosentan and Cyclosporine together?
No — this combination should generally be avoided. Do not coadminister. Choose an alternative pulmonary hypertension treatment or immunosuppressant.
What is the severity of this interaction?
The interaction between Bosentan and Cyclosporine is classified as Major — avoid combination. Cyclosporine inhibits hepatic uptake and CYP3A4-mediated clearance of bosentan, markedly increasing bosentan exposure. Bosentan can also induce CYP3A4 and reduce cyclosporine concentrations.
What should I do if I'm prescribed both?
Do not coadminister. Choose an alternative pulmonary hypertension treatment or immunosuppressant. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.