Amiodarone and Clarithromycin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Amiodarone and Clarithromycin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Amiodarone interacts with Clarithromycin

Both drugs prolong cardiac repolarization through effects on potassium channels, and clarithromycin may inhibit amiodarone metabolism via CYP3A4. The combination increases risk of QT prolongation and torsades de pointes.

What you should do

Avoid coadministration where possible; choose a non-QT-prolonging antibiotic and monitor ECG and electrolytes if no alternative exists.

Key facts

Severity

Major — avoid combination

Mechanism

Both drugs prolong cardiac repolarization through effects on potassium channels, and clarithromycin may inhibit amiodaro...

Action

Avoid coadministration where possible; choose a non-QT-prolonging antibiotic and monitor ECG and electrolytes if no alte...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amiodarone and Clarithromycin together?

No — this combination should generally be avoided. Avoid coadministration where possible; choose a non-QT-prolonging antibiotic and monitor ECG and electrolytes if no alternative exists.

What is the severity of this interaction?

The interaction between Amiodarone and Clarithromycin is classified as Major — avoid combination. Both drugs prolong cardiac repolarization through effects on potassium channels, and clarithromycin may inhibit amiodarone metabolism via CYP3A4. The combination increases risk of QT prolongation and torsades de pointes.

What should I do if I'm prescribed both?

Avoid coadministration where possible; choose a non-QT-prolonging antibiotic and monitor ECG and electrolytes if no alternative exists. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.