Aciclovir and Tenofovir Disoproxil: Drug Interaction Guide
Quick answer: This combination requires caution. Aciclovir and Tenofovir Disoproxil can be used together with adjustments and monitoring.
How Aciclovir interacts with Tenofovir Disoproxil
Both drugs undergo renal elimination and can cause proximal tubular injury, producing additive nephrotoxicity and reduced renal clearance.
What you should do
Assess renal function before and during combined therapy, ensure adequate hydration, and adjust doses for renal impairment. Consider a less nephrotoxic alternative in high-risk patients.
Key facts
Severity
Moderate — caution required
Mechanism
Both drugs undergo renal elimination and can cause proximal tubular injury, producing additive nephrotoxicity and reduce...
Action
Assess renal function before and during combined therapy, ensure adequate hydration, and adjust doses for renal impairme...
Frequently asked questions
Can I take Aciclovir and Tenofovir Disoproxil together?
With caution. Assess renal function before and during combined therapy, ensure adequate hydration, and adjust doses for renal impairment. Consider a less nephrotoxic alternative in high-risk patients.
What is the severity of this interaction?
The interaction between Aciclovir and Tenofovir Disoproxil is classified as Moderate — caution required. Both drugs undergo renal elimination and can cause proximal tubular injury, producing additive nephrotoxicity and reduced renal clearance.
What should I do if I'm prescribed both?
Assess renal function before and during combined therapy, ensure adequate hydration, and adjust doses for renal impairment. Consider a less nephrotoxic alternative in high-risk patients. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.