Aciclovir and Tenofovir: Drug Interaction Guide

Quick answer: This combination requires caution. Aciclovir and Tenofovir can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Aciclovir interacts with Tenofovir

Both drugs undergo renal tubular handling and can cause proximal tubular injury; competition for renal organic anion transporters may also increase exposure.

What you should do

Assess renal function before and during combined therapy, ensure adequate hydration, and adjust doses for renal impairment.

Key facts

Severity

Moderate — caution required

Mechanism

Both drugs undergo renal tubular handling and can cause proximal tubular injury; competition for renal organic anion tra...

Action

Assess renal function before and during combined therapy, ensure adequate hydration, and adjust doses for renal impairme...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Aciclovir and Tenofovir together?

With caution. Assess renal function before and during combined therapy, ensure adequate hydration, and adjust doses for renal impairment.

What is the severity of this interaction?

The interaction between Aciclovir and Tenofovir is classified as Moderate — caution required. Both drugs undergo renal tubular handling and can cause proximal tubular injury; competition for renal organic anion transporters may also increase exposure.

What should I do if I'm prescribed both?

Assess renal function before and during combined therapy, ensure adequate hydration, and adjust doses for renal impairment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.