Diclofenac and Tenofovir Disoproxil: Drug Interaction Guide

Quick answer: This combination requires caution. Diclofenac and Tenofovir Disoproxil can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Diclofenac interacts with Tenofovir Disoproxil

Diclofenac can reduce renal perfusion and may interfere with renal tubular transport, compounding tenofovir-associated proximal tubular toxicity and acute kidney injury.

What you should do

Prefer an alternative analgesic, especially in patients with renal risk factors. If combined, use the lowest NSAID dose and monitor renal function, phosphate, and urinalysis.

Key facts

Severity

Moderate — caution required

Mechanism

Diclofenac can reduce renal perfusion and may interfere with renal tubular transport, compounding tenofovir-associated p...

Action

Prefer an alternative analgesic, especially in patients with renal risk factors. If combined, use the lowest NSAID dose ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Diclofenac and Tenofovir Disoproxil together?

With caution. Prefer an alternative analgesic, especially in patients with renal risk factors. If combined, use the lowest NSAID dose and monitor renal function, phosphate, and urinalysis.

What is the severity of this interaction?

The interaction between Diclofenac and Tenofovir Disoproxil is classified as Moderate — caution required. Diclofenac can reduce renal perfusion and may interfere with renal tubular transport, compounding tenofovir-associated proximal tubular toxicity and acute kidney injury.

What should I do if I'm prescribed both?

Prefer an alternative analgesic, especially in patients with renal risk factors. If combined, use the lowest NSAID dose and monitor renal function, phosphate, and urinalysis. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.