Labor and Delivery: Complete Guide to Childbirth
📊 Quick Facts About Labor and Delivery
💡 Key Things to Know About Labor and Delivery
- The 5-1-1 rule: Go to the hospital when contractions are 5 minutes apart, last 1 minute each, for 1 hour
- Labor has three stages: Cervical dilation, pushing/delivery, and placenta delivery
- First births take longer: Expect 12-18 hours total; subsequent births are typically 6-12 hours
- Multiple pain relief options: Epidural, nitrous oxide, IV medications, and non-pharmacological methods
- Water breaking: Go to the hospital even without contractions; note the color and time
- Warning signs requiring immediate care: Heavy bleeding, severe headache, decreased fetal movement, fever
- Skin-to-skin contact: Immediately after birth promotes bonding and helps regulate baby's temperature
What Is Labor and How Does It Begin?
Labor is the process by which your body prepares for and accomplishes the birth of your baby. It begins when regular, progressively stronger contractions start to dilate (open) your cervix. True labor contractions don't go away with rest, become more frequent over time, and cause cervical change. Labor typically begins spontaneously between 37-42 weeks of pregnancy.
Labor represents one of the most profound physiological processes the human body undergoes. During labor, coordinated contractions of the uterine muscle work systematically to accomplish two primary goals: dilating the cervix from closed to 10 centimeters, and then expelling the baby through the birth canal. This complex process involves hormonal cascades, mechanical forces, and remarkable maternal-fetal coordination that has evolved over millions of years.
The onset of labor involves several interrelated changes in your body. Hormonal shifts trigger the softening and thinning of the cervix (effacement), while prostaglandins help prepare the uterine tissue for contractions. Oxytocin, often called the "love hormone," plays a central role in stimulating and maintaining the rhythmic contractions that characterize active labor. These hormonal changes typically begin days or even weeks before active labor, though you may not notice them immediately.
Understanding what constitutes true labor versus false labor (Braxton Hicks contractions) is crucial for knowing when to seek medical care. True labor contractions are characterized by regularity, increasing intensity, and progression in frequency. Unlike Braxton Hicks contractions, which tend to be irregular and diminish with rest or hydration, true labor contractions persist and strengthen regardless of activity level or position changes.
Prelabor Signs and Symptoms
In the days and weeks leading up to labor, many women experience preliminary signs that the body is preparing for birth. These prelabor signs don't necessarily mean labor is imminent but indicate that your body is getting ready. Lightening, when the baby drops lower into the pelvis, may occur two to four weeks before labor in first-time mothers, though it often happens later or even during labor for subsequent pregnancies. This shift can relieve pressure on the diaphragm, making breathing easier, while increasing pelvic pressure and urinary frequency.
The loss of the mucus plug, sometimes called "bloody show," is another common prelabor sign. This thick, gelatinous discharge may be clear, pink, or blood-tinged and indicates that the cervix is beginning to dilate. While losing the mucus plug suggests labor is approaching, it can occur days or even weeks before contractions begin. Increased vaginal discharge, lower back pain, loose stools, and a burst of energy (often called "nesting") are additional signs that labor may be near.
How Hormones Trigger Labor
The initiation of labor involves a complex hormonal dance between mother and baby. Research suggests that signals from the mature fetal lungs trigger the initial cascade of events. As the baby's lungs mature, they release surfactant, a substance that signals the mother's body that the baby is ready for life outside the womb. This triggers a shift in the hormonal balance, with decreasing progesterone (which maintains pregnancy) and increasing estrogen, prostaglandins, and oxytocin (which promote labor).
Oxytocin receptors in the uterus increase dramatically near the end of pregnancy, making the uterine muscle increasingly responsive to this contraction-promoting hormone. The baby's head pressing on the cervix further stimulates oxytocin release through a positive feedback loop, helping to establish and maintain regular contractions. Understanding these physiological processes can help expecting parents appreciate the remarkable coordination required for successful labor and delivery.
What Are the Signs That Labor Is Starting?
Signs that labor is starting include regular contractions that become stronger and closer together, water breaking (rupture of membranes), bloody show (mucus plug discharge), persistent lower back pain, and increased pelvic pressure. True labor contractions don't stop with rest or position changes and progressively intensify, typically starting 15-20 minutes apart and eventually reaching 5 minutes apart or less.
Recognizing the onset of labor is a crucial skill for expectant parents, as it determines when to contact healthcare providers and head to the birthing facility. The challenge lies in distinguishing true labor from the false alarms that can occur in late pregnancy. True labor produces consistent, progressive changes, while false labor tends to be irregular and non-progressive. Understanding these distinctions can reduce unnecessary hospital visits while ensuring you receive timely care when labor truly begins.
The hallmark sign of labor is regular uterine contractions that cause cervical change. These contractions typically begin as mild cramping sensations, similar to menstrual cramps, and gradually increase in intensity, duration, and frequency. Early labor contractions may occur every 15-20 minutes and last 30-60 seconds. As labor progresses, contractions become more frequent (eventually reaching every 2-3 minutes) and longer (lasting 60-90 seconds), with increasing intensity that makes walking and talking difficult during contractions.
Many women describe labor contractions as a wavelike sensation that builds to a peak and then gradually subsides. The pain typically begins in the lower back and radiates around to the front of the abdomen. Unlike Braxton Hicks contractions, which are often felt only in the front of the abdomen and may be relieved by changing position, true labor contractions persist regardless of activity and become progressively stronger over time. Timing your contractions from the start of one to the start of the next helps determine their frequency and regularity.
Water Breaking
Rupture of membranes, commonly called "water breaking," occurs when the amniotic sac surrounding your baby breaks, releasing amniotic fluid. This can happen as a dramatic gush or as a slow trickle that may be mistaken for urine. Contrary to popular movie depictions, only about 10-15% of labors begin with water breaking before contractions start. For most women, membranes rupture during active labor or are artificially ruptured by healthcare providers.
When your water breaks, note the time and the characteristics of the fluid. Normal amniotic fluid is clear or slightly yellow and has a mild, not unpleasant odor. Green or brown-tinged fluid may indicate meconium (baby's first stool) and requires prompt evaluation. Regardless of whether contractions have started, contact your healthcare provider when your water breaks, as the risk of infection increases once the protective membrane is no longer intact. Most providers recommend delivering within 24 hours of membrane rupture.
Bloody Show and Cervical Changes
The bloody show refers to the discharge of the mucus plug that has sealed the cervix throughout pregnancy. As the cervix begins to soften, thin, and dilate, this plug is released. The mucus may be clear, pink, or blood-streaked and has a thick, jelly-like consistency. While the loss of the mucus plug indicates that cervical changes are occurring, it's not a reliable indicator of when labor will begin - some women lose it weeks before labor, while others don't notice it at all.
Light vaginal bleeding or spotting is common in late pregnancy, especially after cervical examinations or intercourse. However, heavy bleeding (similar to a menstrual period or heavier) requires immediate medical attention, as it may indicate placental problems. Any bright red bleeding, bleeding accompanied by severe pain, or bleeding with clots should prompt an immediate call to your healthcare provider or trip to the hospital.
- Heavy vaginal bleeding (soaking a pad in less than an hour)
- Severe, constant abdominal pain (not the rhythmic pain of contractions)
- Decreased fetal movement (less than 10 movements in 2 hours)
- Severe headache with vision changes or swelling
- Fever above 38°C (100.4°F)
- Green or brown-tinged amniotic fluid
When Should I Go to the Hospital During Labor?
Use the 5-1-1 rule: go to the hospital when contractions are 5 minutes apart, last 1 minute each, and have continued for 1 hour. Go immediately if your water breaks, you have heavy bleeding, decreased fetal movement, severe headache with vision changes, or if you have a high-risk pregnancy. First-time mothers should also call when they're uncertain - your healthcare team can help assess your progress.
Knowing when to go to the hospital is one of the most common concerns for expectant parents. Arriving too early may result in being sent home or having a longer, less comfortable hospital stay, while arriving too late raises concerns about delivering en route or without adequate medical support. The 5-1-1 rule provides a practical guideline, though individual circumstances may warrant earlier or later arrival. Discussing your specific situation with your healthcare provider during prenatal visits helps establish personalized guidance.
For first-time mothers, the 5-1-1 rule (contractions 5 minutes apart, lasting 1 minute each, for at least 1 hour) generally indicates active labor and an appropriate time to head to the hospital. However, if you live far from the hospital, have a history of rapid labor, or have specific risk factors, your provider may recommend coming in sooner. Some providers suggest the 4-1-1 or even 3-1-1 rule for mothers who have had previous rapid labors or who live more than 30 minutes from the hospital.
The timing guidelines differ for subsequent pregnancies, as labor typically progresses faster after the first birth. If you've had a previous vaginal delivery, consider using the 5-1-1 rule as a minimum guideline, but be prepared to leave sooner if contractions rapidly intensify. Some experienced mothers find that their labor progresses quickly once it begins, making the "1 hour" component less relevant. Trust your instincts - if something feels different or concerning, contact your healthcare provider.
Situations Requiring Immediate Hospital Visit
Certain situations warrant immediate hospital evaluation regardless of contraction pattern. If your water breaks, go to the hospital even without contractions, as your healthcare team will want to verify that the fluid is amniotic fluid and monitor for signs of infection or umbilical cord complications. Note the time your water broke and describe the color and amount of fluid to your healthcare team.
Heavy vaginal bleeding, severe abdominal pain that doesn't follow a contraction pattern, decreased fetal movement, or symptoms of preeclampsia (severe headache, vision changes, upper abdominal pain, significant swelling) require immediate evaluation. If you have a high-risk pregnancy due to conditions such as gestational diabetes, preeclampsia, placenta previa, or previous cesarean section, your provider may recommend earlier hospital arrival or have specific instructions for when to come in.
Pack your hospital bag several weeks before your due date. Essential items include identification and insurance information, your birth plan, comfortable clothes for labor and postpartum, toiletries, phone charger, going-home outfit for you and baby, and car seat (required for discharge). Many hospitals provide newborn essentials, but check with your facility about what to bring.
What Are the Three Stages of Labor?
Labor has three stages: The first stage involves cervical dilation from 0 to 10 cm and is divided into early labor (0-6 cm), active labor (6-8 cm), and transition (8-10 cm). The second stage is the pushing phase, lasting from full dilation until your baby is born. The third stage involves delivery of the placenta, typically occurring within 30 minutes of birth. Understanding each stage helps you know what to expect and cope effectively.
Labor is traditionally divided into three distinct stages, each with characteristic features and challenges. The first stage is typically the longest, involving the gradual opening of the cervix to allow the baby to pass through. The second stage, often called the "pushing" stage, involves the active work of pushing your baby through the birth canal. The third stage, often overlooked in prenatal discussions, involves the delivery of the placenta. Understanding what happens during each stage can help you feel more prepared and work effectively with your healthcare team.
First Stage: Cervical Dilation
The first stage of labor begins with the onset of regular contractions and ends when the cervix is fully dilated to 10 centimeters. This stage is further divided into three phases: early labor, active labor, and transition. Each phase has distinct characteristics in terms of contraction pattern, cervical progress, and the physical and emotional experience of labor.
Early labor (also called the latent phase) involves dilation from 0 to about 6 centimeters. This phase is often the longest, lasting anywhere from hours to days, especially for first-time mothers. Contractions during early labor are typically mild to moderate, occurring every 5-20 minutes and lasting 30-60 seconds. Many women can continue normal activities during early labor, and healthcare providers often recommend staying home during this phase where you can move freely, eat light meals, and rest between contractions.
Active labor begins when the cervix reaches about 6 centimeters and continues to about 8 centimeters. Contractions become stronger, longer (lasting 45-60 seconds), and more frequent (every 3-5 minutes). This is typically when women are admitted to the hospital or birthing center. Active labor requires more focused attention and coping techniques. The cervix typically dilates about 1 centimeter per hour during active labor for first-time mothers, though this rate varies considerably.
Transition is the most intense phase of labor, involving dilation from 8 to 10 centimeters. Contractions may occur every 2-3 minutes and last 60-90 seconds, with little rest between them. Many women describe this phase as overwhelming, with intense pressure, nausea, shaking, and strong emotional responses. The good news is that transition is typically short (15 minutes to an hour for most women) and signals that pushing is near. Healthcare providers offer extra support during this challenging phase.
| Stage/Phase | Cervical Dilation | Duration (First Birth) | Contraction Pattern |
|---|---|---|---|
| Early Labor | 0-6 cm | 6-12 hours | Every 5-20 min, 30-60 sec |
| Active Labor | 6-8 cm | 4-8 hours | Every 3-5 min, 45-60 sec |
| Transition | 8-10 cm | 15 min - 1 hour | Every 2-3 min, 60-90 sec |
| Second Stage (Pushing) | Fully dilated | 1-3 hours | Every 2-4 min with urge to push |
| Third Stage (Placenta) | N/A | 5-30 minutes | Mild contractions |
Second Stage: Pushing and Delivery
The second stage of labor begins when the cervix is fully dilated (10 cm) and ends with the birth of your baby. This is the active pushing phase, where you work with your contractions to move your baby through the birth canal. For first-time mothers, this stage averages 1-3 hours, while subsequent births typically involve shorter pushing phases of 5-30 minutes. Various factors influence pushing duration, including baby's position, epidural use, and maternal pushing technique.
During the second stage, you'll feel an overwhelming urge to push with each contraction. This urge, caused by the baby's head pressing on the pelvic floor, is nature's signal that it's time to actively participate in delivery. Your healthcare team will guide your pushing efforts, helping you work effectively with each contraction. Different pushing positions (squatting, side-lying, hands-and-knees, or using a birthing bar) can help your baby descend and may reduce the pushing phase duration.
As your baby's head crowns (becomes visible at the vaginal opening), you may feel an intense stretching sensation called the "ring of fire." Your healthcare provider may ask you to stop pushing briefly to allow the perineum to stretch gradually, reducing the risk of tearing. Once the head is delivered, the shoulders and body typically follow quickly with one or two more pushes. The moment of birth is often accompanied by overwhelming emotions and the first cries of your newborn.
Third Stage: Delivery of the Placenta
The third stage of labor involves the delivery of the placenta, the remarkable organ that has nourished your baby throughout pregnancy. This stage begins immediately after your baby is born and typically lasts 5-30 minutes. Mild contractions continue, causing the placenta to separate from the uterine wall and be expelled. Your healthcare provider may ask you to push gently to help deliver the placenta, and may apply gentle traction on the umbilical cord.
Active management of the third stage, which includes administering oxytocin after delivery and controlled cord traction, has been shown to reduce postpartum bleeding and is standard practice in most settings. Your healthcare provider will examine the placenta to ensure it's complete, as retained placental fragments can cause bleeding or infection. After placenta delivery, your uterus continues to contract, helping to control bleeding and begin the process of returning to its pre-pregnancy size.
What Pain Relief Options Are Available During Labor?
Pain relief options during labor include epidural anesthesia (most effective, used by 60-70% of women in developed countries), nitrous oxide (laughing gas), IV medications like fentanyl, spinal blocks, and non-pharmacological methods such as water immersion, massage, breathing techniques, and movement. The choice depends on personal preference, labor progress, and medical factors. You can change your plan as labor progresses.
Managing labor pain is a highly individual choice, and there's no single "right" approach. Some women prefer to experience labor with minimal medical intervention, using breathing, movement, and support to cope with contractions. Others find pharmacological pain relief essential for a positive birth experience. Most women fall somewhere in between, remaining open to various options as labor progresses. Understanding available choices before labor allows you to make informed decisions in partnership with your healthcare team.
The intensity of labor pain varies considerably between women and between births for the same woman. Factors influencing pain perception include baby's position, labor duration, previous birth experiences, and individual pain sensitivity. Cultural background, expectations, and emotional support also play significant roles in how women experience and cope with labor pain. Regardless of which pain relief methods you choose, adequate support from partners, family, and healthcare providers consistently improves the birth experience.
Epidural Anesthesia
Epidural anesthesia is the most effective form of pain relief during labor and is used by 60-70% of women in many developed countries. An epidural involves placing a thin catheter in the epidural space surrounding the spinal cord, through which local anesthetic and sometimes low-dose opioids are continuously infused. This blocks pain signals from the lower body while typically allowing some sensation and movement, enabling participation in pushing.
The procedure takes about 10-20 minutes to place and an additional 10-20 minutes for full effect. An anesthesiologist or nurse anesthetist administers the epidural, which can be given at any point during labor, though it's typically requested during active labor. Modern "walking epidurals" use lower doses that may allow some mobility, though most women with epidurals remain in bed. The catheter remains in place throughout labor, allowing continuous pain relief or additional doses as needed.
Benefits of epidural anesthesia include excellent pain relief, reduced maternal stress hormones, and the ability to rest during a long labor. Potential downsides include temporary blood pressure decrease, longer pushing stage, increased likelihood of instrumental delivery (forceps or vacuum), and rare complications such as headache or temporary leg weakness. Epidurals don't increase cesarean section rates in low-risk women, contrary to previous beliefs. Discuss the pros and cons with your healthcare provider to determine if epidural is right for you.
Nitrous Oxide (Laughing Gas)
Nitrous oxide, commonly called laughing gas, provides mild to moderate pain relief and reduces anxiety during labor. It's self-administered through a handheld mask, giving you control over when and how much you use. The effects begin within seconds and wear off quickly when you stop inhaling, making it easy to adjust throughout labor. Nitrous oxide doesn't eliminate pain but helps many women cope better with contractions.
The mixture used in labor contains 50% nitrous oxide and 50% oxygen, a safe concentration that doesn't affect the baby or slow labor. Side effects may include nausea, dizziness, or drowsiness in some women. Nitrous oxide can be used at any stage of labor and is compatible with other pain relief methods - you can use it alone or while waiting for an epidural to take effect. It's particularly popular among women who want some pain relief without the commitment of regional anesthesia.
Non-Pharmacological Methods
Many effective pain management techniques don't involve medication. These methods can be used alone or combined with pharmacological options. Hydrotherapy (laboring in water) provides buoyancy that reduces muscle tension and promotes relaxation. Warm water immersion during labor has been shown to reduce pain and anxiety without adverse effects on labor progression or newborn outcomes.
Movement and positioning allow gravity to assist labor while helping you find comfortable positions. Walking, swaying, using a birthing ball, or hands-and-knees positioning can ease back labor and help the baby descend. Staying upright and mobile during early labor is associated with shorter labor duration. Massage and counter-pressure, especially on the lower back, provide physical comfort and emotional support. Partners can be taught specific techniques during prenatal classes.
Breathing techniques and relaxation help manage the intensity of contractions by promoting oxygen flow and reducing tension. Focused breathing, visualization, and progressive relaxation are core components of many childbirth preparation methods. Continuous labor support from a partner, doula, or trained support person has been shown to reduce pain medication use, shorten labor, and improve satisfaction with the birth experience.
What Complications Can Occur During Labor?
Common labor complications include prolonged labor (failure to progress), fetal distress, umbilical cord problems, abnormal fetal positioning, heavy bleeding, and infection. Most complications can be managed effectively with medical intervention. Your healthcare team continuously monitors you and your baby to detect and address problems early. Being at a birthing facility with emergency capabilities ensures rapid response if complications arise.
While most labors progress normally, complications can occur that require medical intervention. Understanding potential problems helps you recognize warning signs and appreciate the monitoring that occurs during labor. Modern obstetric care includes continuous assessment of maternal and fetal well-being, allowing early detection and management of most complications. The goal is always the safest possible delivery for both mother and baby.
Prolonged labor or failure to progress occurs when labor stalls despite adequate contractions. This may happen during cervical dilation or the pushing stage. Causes include ineffective contractions, unfavorable fetal position, or cephalopelvic disproportion (baby too large for the pelvis). Treatment options include oxytocin augmentation, artificial membrane rupture, position changes, or cesarean section if vaginal delivery isn't progressing safely.
Fetal distress refers to signs that the baby isn't tolerating labor well, typically detected through abnormal fetal heart rate patterns on the monitor. Causes include umbilical cord compression, placental problems, or maternal factors. Initial management involves position changes, oxygen administration, and IV fluids. If the baby doesn't respond, expedited delivery via instrumental assistance or cesarean section may be necessary.
When Cesarean Section Becomes Necessary
Cesarean section (C-section) is surgical delivery through incisions in the abdomen and uterus. While some cesareans are planned in advance for known medical reasons, others become necessary during labor. Indications include failure to progress, fetal distress, umbilical cord prolapse, placental problems, or unfavorable fetal position. Emergency cesareans are performed quickly when immediate delivery is needed, while urgent cesareans allow more preparation time.
Understanding that cesarean delivery may become necessary, even with a planned vaginal birth, helps with mental preparation. Cesarean births are safe and common, representing about 30% of deliveries in many countries. Recovery takes longer than vaginal birth, but most women heal well with proper care. If cesarean becomes necessary, your healthcare team will explain the reasons and involve you in decisions when time permits.
What Happens Immediately After the Baby Is Born?
Immediately after birth, your baby is placed on your chest for skin-to-skin contact, which helps regulate body temperature, stabilizes heart rate, and promotes bonding and breastfeeding. The umbilical cord is clamped and cut, often by the partner. The baby receives Apgar assessments at 1 and 5 minutes. The placenta delivers within 30 minutes. Your healthcare team checks for tears and monitors your recovery while you bond with your newborn.
The moments after birth are a critical transition time for both you and your baby. Immediately after delivery, your baby undergoes remarkable physiological changes, transitioning from intrauterine to extrauterine life. The first breath inflates the lungs, and the circulatory system redirects blood flow. Meanwhile, you experience powerful hormonal surges that promote bonding, breastfeeding, and uterine contraction to control bleeding.
Skin-to-skin contact, placing your naked baby directly on your bare chest, is standard practice immediately after delivery for healthy mothers and babies. This simple act provides numerous benefits: it helps regulate your baby's temperature, heart rate, and breathing; promotes early breastfeeding; enhances bonding; and reduces stress for both of you. Skin-to-skin contact is recommended for at least the first hour after birth, or until after the first breastfeed.
The Apgar score is a quick assessment of your baby's condition at 1 minute and 5 minutes after birth. Healthcare providers evaluate five criteria - heart rate, breathing, muscle tone, reflexes, and color - assigning a score of 0, 1, or 2 for each. Most healthy babies score 7-10. The Apgar test is performed while your baby is on your chest or nearby and doesn't require separation. A lower score may indicate the need for assistance with breathing or other supportive care.
Umbilical Cord Clamping and Cutting
The umbilical cord continues to pulse for several minutes after birth, transferring blood and iron from the placenta to your baby. Delayed cord clamping (waiting at least 30-60 seconds before clamping) is now recommended by WHO and other organizations, as it increases the baby's iron stores and reduces the risk of anemia in the first months of life. After clamping, the cord is cut - often by the birth partner if desired - and a small plastic clamp remains on the baby's cord stump until it falls off naturally in 1-2 weeks.
Perineal Care and Recovery
During delivery, the perineum (tissue between the vagina and rectum) stretches significantly. Some women experience tears that require repair with dissolvable stitches. First and second-degree tears are common and heal well with proper care. More extensive tears are less common but may require additional support during recovery. Ice packs, sitz baths, and proper hygiene help with healing. Your healthcare provider will examine you after delivery and repair any tears.
In the hours after delivery, you'll be monitored for excessive bleeding, uterine firmness, and overall recovery. You may experience shaking (a normal hormonal response), hunger, and a range of emotions. Your healthcare team will help with breastfeeding initiation if desired and answer questions about newborn care. Most women are transferred to a postpartum room within a few hours, where they continue recovering while getting to know their new baby.
Frequently Asked Questions About Labor and Delivery
Medical References and Sources
This article is based on current medical research and international guidelines. All claims are supported by scientific evidence from peer-reviewed sources.
- World Health Organization (2018). "WHO recommendations: intrapartum care for a positive childbirth experience." WHO Publications Comprehensive evidence-based guidelines for labor and delivery care. Evidence level: 1A
- American College of Obstetricians and Gynecologists (2024). "ACOG Practice Bulletins: Labor and Delivery." ACOG Clinical guidelines for obstetric care in the United States.
- National Institute for Health and Care Excellence (2023). "Intrapartum care for healthy women and babies (CG190)." NICE Guidelines UK national guidelines for intrapartum care.
- Cochrane Database of Systematic Reviews (2023). "Pain management for women in labour: an overview of systematic reviews." Cochrane Library Systematic review of labor pain management options. Evidence level: 1A
- American Academy of Pediatrics (2024). "Delayed Umbilical Cord Clamping After Birth: AAP Clinical Report." Guidelines on optimal timing for umbilical cord clamping.
- Bohren MA, et al. (2017). "Continuous support for women during childbirth." Cochrane Database of Systematic Reviews. Evidence for the benefits of continuous labor support.
Evidence grading: This article uses the GRADE framework (Grading of Recommendations Assessment, Development and Evaluation) for evidence-based medicine. Evidence level 1A represents the highest quality of evidence, based on systematic reviews of randomized controlled trials.
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