Skin-to-Skin Contact: Benefits for Newborn Bonding
📊 Quick Facts About Skin-to-Skin Contact
💡 Key Takeaways About Skin-to-Skin Contact
- Start immediately after birth: The first hour after birth (the "golden hour") is ideal for initiating skin-to-skin contact
- Benefits are scientifically proven: WHO recommends skin-to-skin for all newborns, especially preterm and low-birth-weight babies
- Regulates baby's vital signs: Skin-to-skin helps stabilize temperature, heart rate, breathing, and blood sugar levels
- Fathers can do it too: The benefits are the same regardless of which parent provides the skin-to-skin contact
- Promotes successful breastfeeding: Babies who have early skin-to-skin contact latch better and breastfeed longer
- Releases bonding hormones: Both parent and baby experience increased oxytocin, promoting calm and attachment
- Safe positioning is essential: Baby should be upright on chest with face visible and airways clear at all times
What Is Skin-to-Skin Contact?
Skin-to-skin contact involves placing a naked or diaper-only newborn directly against a parent's bare chest, providing warmth, comfort, and promoting physiological stability. Also called kangaroo care, this practice is recommended by WHO for all newborns and is especially beneficial for premature infants.
Skin-to-skin contact is a simple yet powerful caregiving practice where your newborn baby lies directly on your bare chest, with their skin touching your skin. The baby can be completely naked or wearing only a diaper, while you remove your shirt and bra (if applicable) to maximize the contact area. This ancient practice, which mimics how humans have naturally cared for infants throughout history, has profound effects on both the baby's physical health and the parent-child bond.
The practice gained modern medical recognition through the development of "kangaroo mother care" (KMC) in Colombia in the 1970s. Faced with a shortage of incubators and high mortality rates among premature infants, physicians discovered that continuous skin-to-skin contact with the mother could dramatically improve survival rates. Since then, extensive research has confirmed that skin-to-skin contact benefits all newborns, not just those born prematurely.
When your baby is held skin-to-skin, they experience a seamless transition from the womb to the outside world. They can hear your familiar heartbeat, feel your warmth, smell your scent, and regulate their own body functions by synchronizing with yours. This biological synchrony helps your newborn adapt to their new environment while maintaining the security and comfort they knew in utero.
The World Health Organization (WHO) strongly recommends immediate and uninterrupted skin-to-skin contact for all newborns, regardless of birth weight, gestational age, or delivery method. This recommendation applies to healthy term infants as well as premature and low-birth-weight babies who are clinically stable.
Why Newborns Need Close Physical Contact
Newborn babies are born expecting to be held. Unlike some mammals who can walk shortly after birth, human infants are completely dependent on their caregivers for survival. This dependency is not just about feeding and warmth - it extends to the fundamental regulation of their body systems. When a newborn is separated from their parent's body, their stress hormones increase, their temperature drops, and their metabolic stability is challenged.
The need for close physical contact is hardwired into human biology. Babies who experience frequent skin-to-skin contact cry less, sleep more peacefully, and show better developmental outcomes. This is because the close contact helps their immature nervous systems regulate and develop optimally. The parent's body essentially acts as an external regulator for the baby's internal systems during the critical first weeks and months of life.
The "Fourth Trimester" Concept
Many pediatric experts describe the first three months after birth as the "fourth trimester" - a period when babies still need womb-like conditions to thrive. Skin-to-skin contact recreates many aspects of the uterine environment: constant warmth, the sound of the heartbeat, gentle movement, and the feeling of being contained. This helps ease the dramatic transition from womb to world and supports optimal development during this critical period.
What Are the Benefits of Skin-to-Skin Contact?
Skin-to-skin contact provides multiple proven benefits including temperature regulation, stabilized heart rate and breathing, better blood sugar control, enhanced bonding through oxytocin release, improved breastfeeding success, reduced crying, and better sleep. For premature babies, it reduces mortality by up to 36% and infections by 40%.
The benefits of skin-to-skin contact have been extensively studied and documented in peer-reviewed medical literature. These benefits extend to the baby, the parent, and the long-term parent-child relationship. The effects are particularly pronounced when skin-to-skin contact begins immediately after birth and continues frequently during the newborn period.
Research published in The Lancet and other leading medical journals has demonstrated that skin-to-skin contact is not just a nice-to-have comfort measure - it is a medical intervention with measurable health outcomes. For premature and low-birth-weight infants, immediate kangaroo mother care has been shown to reduce mortality by up to 36% compared to conventional incubator care, making it one of the most effective interventions available for this vulnerable population.
Temperature Regulation
One of the most immediate and important benefits of skin-to-skin contact is temperature regulation. Newborns, especially premature infants, have difficulty maintaining their body temperature because they have limited body fat, a large surface area relative to their weight, and immature thermoregulation systems. When held skin-to-skin, the parent's body automatically adjusts to keep the baby at the optimal temperature.
Research has shown that a parent's chest temperature actually responds to the baby's needs - if the baby is too cold, the parent's chest temperature increases; if the baby is too warm, it decreases. This phenomenon, called "thermal synchrony," is more effective and gentle than artificial warming methods and eliminates the risk of overheating that can occur with incubators or heating pads.
Stabilized Breathing and Heart Rate
Babies held in skin-to-skin contact show more stable heart rates and breathing patterns compared to those in incubators or bassinets. The rhythmic rise and fall of the parent's chest, combined with the sound of the heartbeat, seems to help regulate the baby's own cardiovascular and respiratory systems. Studies have documented fewer episodes of apnea (temporary cessation of breathing) and bradycardia (slowed heart rate) in premature infants receiving kangaroo care.
Improved Blood Sugar Control
Newborns are at risk of hypoglycemia (low blood sugar) in the hours after birth as they transition from receiving continuous glucose through the placenta to metabolizing their own energy. Skin-to-skin contact helps stabilize blood glucose levels by reducing stress hormones and energy expenditure while facilitating early and frequent breastfeeding. This is particularly important for babies who are small for gestational age or have other risk factors for hypoglycemia.
Enhanced Bonding Through Oxytocin
Skin-to-skin contact triggers the release of oxytocin, often called the "love hormone" or "bonding hormone," in both the parent and the baby. This hormone promotes feelings of calm, reduces stress, and enhances the emotional connection between parent and child. Oxytocin also helps stimulate milk production in breastfeeding mothers and promotes nurturing behaviors in all caregivers.
The release of oxytocin during skin-to-skin contact creates a positive feedback loop: the close contact feels good, which encourages more contact, which releases more oxytocin, which strengthens the bond. This hormonal response helps parents feel more confident and attuned to their baby's needs, which supports better caregiving overall.
Improved Breastfeeding Success
Babies who have early and frequent skin-to-skin contact are more likely to breastfeed successfully. When placed skin-to-skin on the mother's chest shortly after birth, babies often demonstrate the "breast crawl" - an instinctive movement toward the breast where they can self-attach and begin feeding. Studies show that babies who have skin-to-skin contact in the first hour after birth are more likely to latch correctly, breastfeed exclusively, and continue breastfeeding for longer durations.
Reduced Crying and Better Sleep
Babies held in skin-to-skin contact cry significantly less than those who are separated from their parents. Research has documented up to 80% less crying time in babies receiving skin-to-skin care. Additionally, babies in skin-to-skin contact spend more time in quiet alert states and restful sleep, which supports healthy development and gives parents more peaceful bonding time.
Pain Reduction
Skin-to-skin contact has been shown to reduce pain responses in newborns undergoing medical procedures such as blood draws or vaccinations. Studies using both behavioral and physiological measures confirm that babies experience less pain when held skin-to-skin compared to being in a crib or incubator. This makes skin-to-skin contact a valuable non-pharmacological pain management strategy in hospital settings.
Research shows that kangaroo mother care for preterm and low-birth-weight infants reduces the risk of mortality by up to 36%, serious infections by 40%, and hypothermia by 65%. It also promotes better weight gain, shorter hospital stays, and improved neurodevelopmental outcomes. WHO recommends immediate kangaroo care as standard practice for all stable preterm and low-birth-weight infants.
How Do You Do Skin-to-Skin Contact Correctly?
Position your baby chest-down on your bare chest in an upright position with head turned to one side. Ensure the face is visible with nose and mouth uncovered. Sit in a semi-reclined position (30-40 degrees) with good back support. Cover baby's back with a light blanket if needed for warmth. The baby should be as upright as possible to keep airways clear.
Proper positioning during skin-to-skin contact is essential for both safety and effectiveness. When done correctly, skin-to-skin is extremely safe and beneficial. The key principles involve ensuring the baby's airway remains open and visible at all times while maximizing the surface area of skin contact between parent and baby.
Before beginning skin-to-skin, prepare yourself and the environment. Remove your shirt and bra if applicable. Find a comfortable semi-reclined position in bed or a supportive chair - you should be at about a 30-40 degree angle, not lying flat or sitting completely upright. Have a light blanket nearby to drape over the baby's back if the room is cool.
Step-by-Step Positioning
Begin by undressing your baby, leaving only the diaper if you prefer. In cooler environments, you may also leave a hat on the baby to help retain warmth through the head. Place your baby chest-down on your bare chest, positioning them between your breasts or on one side of your chest.
The baby's head should be turned to one side, not face-down into your chest. The head should be in a neutral or slightly extended position - imagine the "sniffing" position used for opening airways, with the chin slightly up rather than tucked down toward the chest. You should always be able to see your baby's face, and the nose and mouth must remain uncovered and unobstructed.
The baby's body should be as upright as possible, with legs in a flexed, frog-like position on either side of your body. This upright positioning helps keep the airway open and allows any milk to stay down after feeding. Avoid letting the baby slump to the side or slide down into a curled position.
Ensuring Safety During Skin-to-Skin
While skin-to-skin contact is very safe when done correctly, there are important safety considerations. Always ensure you can see your baby's face - their color and breathing should be visible to you at all times. The baby's head should never be covered by blankets, your clothing, or pressed against your body in a way that could obstruct breathing.
If you feel drowsy during skin-to-skin contact, ask someone to take the baby or place them in their safe sleep space. Never fall asleep with your baby on your chest in a reclined chair or sofa, as these surfaces pose suffocation risks if you slip into sleep. In hospital settings, nurses monitor skin-to-skin sessions and can help ensure safety.
Duration and Frequency
There is no maximum limit to how long or how often you can do skin-to-skin contact - the more, the better. Ideally, skin-to-skin should begin immediately after birth and continue for at least the first hour (the "golden hour"). After this initial period, continue skin-to-skin as frequently as possible throughout your hospital stay and after returning home.
In the early weeks, aim for several hours of skin-to-skin contact daily. This can be spread throughout the day and night in sessions that work for your schedule. Many parents find that skin-to-skin time during feedings, after diaper changes, or during quiet wakeful periods works well. As your baby grows, skin-to-skin remains beneficial but naturally decreases as the baby becomes more mobile and interested in exploring the world.
Using Baby Carriers and Wraps
For parents who want to maintain skin-to-skin contact while remaining mobile, specially designed baby carriers and wraps can be helpful. When using a carrier, ensure that your baby's face remains visible at all times, that the carrier keeps the baby in an upright position with legs in an M-shape, and that the head is adequately supported but not covered or pressed against your body.
When using carriers for skin-to-skin, the baby may need to wear a diaper and perhaps a light layer of clothing depending on the outside temperature and how much skin contact is possible in your particular carrier. The principles of visible face, clear airway, and supported upright positioning remain the same.
If your newborn needs to be put down for a short time - for example, while you use the bathroom or shower - ensure they are dressed in appropriate clothing including a hat to retain warmth. Place them in a safe sleep space on their back. Return to skin-to-skin contact as soon as possible. Young newborns should not be left alone for extended periods without close physical contact.
Can Fathers Do Skin-to-Skin Contact?
Yes, fathers and all caregivers can and should do skin-to-skin contact. Research confirms that babies experience the same benefits regardless of which parent provides the contact. Fathers doing skin-to-skin also experience increased oxytocin levels and stronger bonding. This is especially valuable during cesarean births or when the mother needs rest.
Skin-to-skin contact is not exclusive to mothers - fathers, partners, and other caregivers can provide this beneficial contact with equal effectiveness. Research has consistently shown that babies receive the same physiological benefits of temperature regulation, stabilized vital signs, and calming effects regardless of whether the skin-to-skin is with the mother, father, or another caregiver.
For fathers, skin-to-skin contact offers a unique opportunity to bond with their newborn in a powerful, physical way. While mothers have nine months of pregnancy to develop a connection with the baby, fathers often feel that their relationship begins at birth. Skin-to-skin contact provides fathers with their own intimate bonding experience, complete with the same oxytocin release that promotes attachment and nurturing instincts.
When Father Skin-to-Skin Is Especially Valuable
There are several situations where father (or partner) skin-to-skin contact is particularly important. During cesarean births, the mother may be in surgery or recovery and temporarily unable to hold the baby. In these cases, the father can provide immediate skin-to-skin contact, ensuring the baby receives the benefits without delay.
When the mother is exhausted after a long labor, recovering from complications, or simply needs rest, the father can take over skin-to-skin duties. This allows the mother to sleep while the baby continues to receive the stabilizing benefits of close contact. It also helps fathers feel confident and competent in caring for their newborn from the very beginning.
For mothers who are struggling with breastfeeding or pumping, having the father do skin-to-skin can relieve some pressure and allow the mother to focus on feeding without also being responsible for all the holding. Some families develop a routine where the father does skin-to-skin after nighttime feedings while the mother goes back to sleep.
Benefits for Fathers
Research has documented increased oxytocin levels in fathers who do skin-to-skin contact with their newborns. This hormonal response promotes bonding and may help fathers feel more connected and confident in their parenting role. Studies have also shown that fathers who do early skin-to-skin are more involved in caregiving tasks throughout infancy and beyond.
Many fathers describe skin-to-skin contact as a transformative experience that helped them truly feel like a parent. The quiet intimacy of holding their naked baby against their chest, feeling the tiny heartbeat and soft breathing, creates memories and attachments that last a lifetime.
Why Is Skin-to-Skin Especially Important for Premature Babies?
Skin-to-skin contact (kangaroo care) is critical for premature babies because it reduces mortality by up to 36%, serious infections by 40%, and hypothermia by 65%. It also improves weight gain, brain development, and breastfeeding success. WHO recommends it as standard care for all stable preterm and low-birth-weight infants instead of incubator care when possible.
For babies born prematurely or with low birth weight, skin-to-skin contact - known as kangaroo mother care (KMC) in this context - is not just beneficial but potentially life-saving. The evidence supporting kangaroo care for preterm infants is so strong that WHO has issued specific recommendations for its immediate implementation in all births of preterm and low-birth-weight babies.
Premature babies face significant challenges that skin-to-skin contact directly addresses. Their temperature regulation systems are underdeveloped, making them prone to hypothermia. Their immune systems are immature, leaving them vulnerable to infections. Their breathing patterns may be irregular, and their feeding abilities are often compromised. Kangaroo mother care provides a natural, effective intervention for all these challenges.
The Evidence for Kangaroo Mother Care
A landmark Cochrane systematic review analyzing data from numerous randomized controlled trials found that kangaroo mother care, compared to conventional incubator care, reduces mortality in low-birth-weight infants by approximately 36%. The same review found a 40% reduction in the risk of serious infections such as sepsis, a 65% reduction in hypothermia, and significant improvements in weight gain.
The WHO 2022 guidelines on preterm and low-birth-weight infant care make a strong recommendation for immediate kangaroo mother care starting as soon as possible after birth, ideally within the first minutes of life for stable infants. The guidelines emphasize that kangaroo care should be provided for as many hours per day as possible - optimally 8 hours or more per day, with continuous 24-hour kangaroo care as the ideal.
How Kangaroo Care Works in Hospitals
In hospital neonatal intensive care units (NICUs), kangaroo care is typically provided as soon as the baby is stable enough to be transferred from the incubator to the parent's chest. Medical staff will help position the baby correctly and monitor vital signs during the initial sessions. Skin-to-skin contact can continue even when the baby has IV lines, oxygen support, or monitoring leads - the equipment is arranged to accommodate the positioning.
Parents are encouraged to spend as much time as possible at the hospital doing skin-to-skin with their premature baby. Some NICUs have facilities for parents to stay overnight to maximize kangaroo care time. Staff can teach parents how to safely transfer the baby between incubator and chest and how to recognize signs that the baby needs a break or additional support.
Long-Term Benefits for Premature Infants
The benefits of kangaroo care extend well beyond the hospital stay. Research has shown that premature infants who received kangaroo mother care have better cognitive and motor development at follow-up, improved emotional regulation, and stronger attachment to their caregivers compared to those who received conventional incubator care alone.
Studies following kangaroo care infants into childhood and adolescence have found lasting positive effects on brain development, stress responses, and parent-child relationships. These long-term benefits make early and sustained kangaroo care one of the most impactful interventions available for premature and low-birth-weight infants.
Is Skin-to-Skin Contact Safe While Sleeping?
Skin-to-skin contact is safest when the parent is awake and alert. If you feel drowsy, place the baby in their safe sleep space. Never do skin-to-skin on a sofa or armchair if you might fall asleep, as this significantly increases SIDS risk. In hospital settings, staff monitor skin-to-skin sessions for safety.
While skin-to-skin contact is extremely safe when done correctly by an alert parent, there are important safety considerations to understand, particularly regarding sleep. The key principle is that skin-to-skin should be practiced by a conscious, aware parent who can monitor the baby's position and breathing continuously.
The main risk associated with skin-to-skin contact occurs when a parent falls asleep while holding the baby, especially on a soft or sloped surface like a sofa, recliner, or armchair. In these situations, there is a risk that the baby could slip into a position that compromises their airway, or become wedged between the parent's body and the furniture. These scenarios are associated with increased risk of sudden infant death syndrome (SIDS) and suffocation.
Safe Practices for Skin-to-Skin
To practice skin-to-skin safely, choose a firm, flat surface when possible. A hospital bed or home bed (without extra pillows and blankets around the baby) is safer than a soft armchair. Sit or recline at an angle that allows you to see your baby's face at all times. Ensure no blankets, sheets, or clothing cover the baby's face or obstruct their breathing.
If you begin to feel drowsy during skin-to-skin time, have a plan in place. Either ask someone else to take the baby, or gently place the baby in their safe sleep space (a firm, flat surface with no loose bedding, toys, or bumpers) before you fall asleep. It is never safe to intentionally co-sleep with a newborn on a soft surface like a sofa.
Hospital Safety Protocols
In hospital settings, nurses and medical staff monitor skin-to-skin sessions to ensure safety. They check that the baby is positioned correctly with visible face and open airway. They may also monitor the baby's vital signs, especially during initial sessions or for premature infants. Staff can provide reminders and assistance if a parent appears to be falling asleep.
Many hospitals use checklists and positioning aids to promote safe skin-to-skin contact. Parents are typically educated about proper positioning before beginning skin-to-skin, and staff remain available to answer questions and provide support throughout the hospital stay.
Never fall asleep with your baby on a couch, recliner, or armchair. These surfaces pose significant suffocation risks. If you are extremely tired, ask someone else to hold the baby or place them in their safe sleep space. In a medical emergency, call your local emergency number immediately.
When Should You Start Skin-to-Skin After a Cesarean Birth?
Skin-to-skin contact can and should begin immediately after cesarean birth if both mother and baby are stable. Many hospitals practice "gentle cesarean" protocols allowing skin-to-skin in the operating room. If the mother cannot do immediate skin-to-skin, the father or partner can provide it instead until the mother is ready.
Cesarean births no longer need to delay the initiation of skin-to-skin contact. With modern "gentle cesarean" or "family-centered cesarean" protocols, many mothers can begin holding their babies skin-to-skin while still in the operating room, immediately after the baby is born and briefly assessed. This represents a significant shift from older practices that routinely separated mothers and babies after surgical births.
During a gentle cesarean, the surgical drapes may be lowered or adjusted so the mother can see her baby being born. The baby is then placed directly on the mother's chest for skin-to-skin contact while the surgical team completes the procedure. Medical staff assist with positioning since the mother's movement is restricted, and they monitor both mother and baby throughout.
When Mother Cannot Do Immediate Skin-to-Skin
There are situations where the mother may not be able to do immediate skin-to-skin after a cesarean delivery. She may be experiencing effects from anesthesia such as nausea or shaking. She may need immediate medical attention for bleeding or other complications. She may simply feel too overwhelmed or uncomfortable to hold the baby right away. In all these situations, the father or partner can step in to provide skin-to-skin contact.
Having the father do skin-to-skin immediately after a cesarean birth ensures the baby receives the stabilizing benefits of close contact without delay. It also gives the father a meaningful role during a birth where they might otherwise feel like a bystander. Once the mother is comfortable and ready, the baby can be transferred to her for continued skin-to-skin contact.
Recovery Room Skin-to-Skin
If skin-to-skin is not possible in the operating room, it should begin as soon as possible in the recovery room. Staff can help position the baby safely on the mother's chest while she is being monitored post-surgery. The mother may need assistance holding the baby securely if she is still experiencing numbness or weakness from the anesthesia.
Studies have shown that early skin-to-skin contact after cesarean birth improves breastfeeding outcomes, reduces maternal stress, and promotes bonding just as effectively as after vaginal birth. The key is to begin as soon as it is safely possible, even if that is somewhat delayed compared to a vaginal delivery.
How Does Skin-to-Skin Contact Affect Your Baby's Brain?
Skin-to-skin contact triggers oxytocin release in both parent and baby, promoting calm and reducing stress hormones. This hormonal environment supports optimal brain development, emotional regulation, and secure attachment formation. Research shows lasting positive effects on cognitive development and stress responses that persist into childhood and adolescence.
The effects of skin-to-skin contact extend deep into the developing brain, influencing both immediate function and long-term development. When a baby is held skin-to-skin, a cascade of hormonal and neurological changes occurs that shapes brain architecture and emotional regulation systems in lasting ways.
The primary hormone involved is oxytocin, which is released in both the parent and the baby during skin-to-skin contact. Oxytocin promotes feelings of calm, reduces stress and anxiety, and enhances social bonding. It also appears to support the development of neural pathways involved in emotional regulation and social connection. Babies who experience frequent oxytocin release through close contact may develop more robust stress-regulation systems.
Stress Reduction and Brain Development
Conversely, skin-to-skin contact reduces levels of cortisol and other stress hormones in newborns. High or prolonged stress hormone exposure in early life can negatively impact brain development, particularly in areas related to learning, memory, and emotional regulation. By keeping stress hormones low, skin-to-skin contact creates an optimal environment for healthy brain development.
Research using brain imaging and developmental assessments has shown that premature infants who received extensive kangaroo mother care have better cognitive and motor development compared to those who received conventional incubator care. These differences persist into childhood, suggesting that early skin-to-skin contact influences brain development in lasting ways.
Attachment and Emotional Development
Skin-to-skin contact supports the development of secure attachment between parent and child. Secure attachment - the feeling that a caregiver is reliably available and responsive - is foundational for healthy emotional development. Children with secure attachments tend to have better emotional regulation, social skills, and psychological well-being throughout life.
The hormonal changes during skin-to-skin, combined with the opportunity for the parent to observe and respond to the baby's cues, creates ideal conditions for attachment formation. Parents become more attuned to their baby's needs, and babies learn that their needs will be met reliably. This early relationship pattern becomes a template for future relationships and emotional health.
Frequently Asked Questions About Skin-to-Skin Contact
Medical References and Sources
This article is based on current medical research and international guidelines. All claims are supported by scientific evidence from peer-reviewed sources.
- World Health Organization (2022). "WHO recommendations for care of the preterm or low birth weight infant." WHO Publications Strong recommendations for immediate kangaroo mother care. Evidence level: 1A
- Conde-Agudelo A, Diaz-Rossello JL. (2016). "Kangaroo mother care to reduce morbidity and mortality in low birthweight infants." Cochrane Database of Systematic Reviews. Cochrane Library Systematic review showing mortality reduction and improved outcomes.
- Moore ER, Bergman N, et al. (2016). "Early skin-to-skin contact for mothers and their healthy newborn infants." Cochrane Database of Systematic Reviews. Review of skin-to-skin benefits for term healthy infants.
- WHO/UNICEF (2018). "Implementation guidance: protecting, promoting and supporting breastfeeding in facilities providing maternity and newborn services - the revised Baby-Friendly Hospital Initiative." WHO Publications Ten Steps to Successful Breastfeeding including skin-to-skin.
- Boundy EO, Dastjerdi R, et al. (2016). "Kangaroo Mother Care and Neonatal Outcomes: A Meta-analysis." Pediatrics. 137(1):e20152238. AAP Publications Meta-analysis confirming KMC benefits across multiple outcomes.
- Feldman R, Eidelman AI. (2003). "Skin-to-skin contact (Kangaroo Care) accelerates autonomic and neurobehavioural maturation in preterm infants." Developmental Medicine and Child Neurology. 45(4):274-281. Research on brain development effects of kangaroo care.
Evidence grading: This article uses the GRADE framework (Grading of Recommendations Assessment, Development and Evaluation) for evidence-based medicine. Evidence level 1A represents the highest quality of evidence, based on systematic reviews of randomized controlled trials.