Menstrual Cramps: Causes, Relief & When to See a Doctor

Medically reviewed | Last reviewed: | Evidence level: 1A
Menstrual cramps (dysmenorrhea) cause cramping pain in the lower abdomen, back, and sometimes radiating to the thighs during menstruation. The pain is typically most severe during the first 1-2 days of your period. While many experience mild discomfort, about 10-15% of women have severe cramps that interfere with daily activities. Effective treatments include over-the-counter pain relievers, heat therapy, and hormonal contraceptives.
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Written and reviewed by iMedic Medical Editorial Team | Specialists in gynecology and women's health

📊 Quick facts about menstrual cramps

Prevalence
50-90%
of menstruating women
Severe cases
10-15%
interfere with daily life
Pain duration
1-3 days
worst on day 1-2
First-line treatment
NSAIDs
ibuprofen, naproxen
Hormonal relief
70-80%
improvement with birth control
ICD-10 code
N94.6
Dysmenorrhea

💡 Key takeaways about menstrual cramps

  • Prostaglandins cause the pain: These hormone-like substances trigger uterine contractions that push out the uterine lining
  • Take pain medication early: NSAIDs like ibuprofen work best when taken at the first sign of symptoms, before severe pain develops
  • Heat therapy is proven effective: Research shows heat pads are as effective as ibuprofen for pain relief
  • Birth control can significantly help: Hormonal contraceptives reduce or eliminate cramps for many women
  • Worsening pain may signal other conditions: Endometriosis, adenomyosis, or fibroids can cause severe secondary dysmenorrhea
  • Exercise can reduce symptoms: Regular physical activity helps decrease menstrual pain intensity over time

What Are Menstrual Cramps?

Menstrual cramps (dysmenorrhea) are throbbing or cramping pains in the lower abdomen that occur before and during menstruation. They are caused by uterine contractions triggered by prostaglandins, hormone-like substances that help shed the uterine lining. The condition affects 50-90% of menstruating women, with 10-15% experiencing severe pain.

Menstrual cramps are one of the most common gynecological conditions, affecting the majority of women at some point during their reproductive years. The medical term for menstrual pain is dysmenorrhea, which comes from the Greek words for "difficult monthly flow." Understanding what causes menstrual cramps and how they differ from other types of pelvic pain is essential for finding effective relief.

The pain typically begins one to two days before menstruation starts and continues into the first two to four days of your period. Most women describe the sensation as a cramping or throbbing pain concentrated in the lower abdomen, though it commonly spreads to the lower back and inner thighs. The intensity can range from a mild, dull ache to severe, debilitating pain that interferes with work, school, and social activities.

Primary dysmenorrhea refers to menstrual pain that occurs without any underlying pelvic condition. This is the most common type and usually begins within a few years after menstruation starts. Secondary dysmenorrhea, on the other hand, is caused by an underlying reproductive disorder such as endometriosis, adenomyosis, or uterine fibroids. Secondary dysmenorrhea often develops later in life and may progressively worsen over time.

Primary vs. Secondary Dysmenorrhea

Primary dysmenorrhea is the cramping pain that comes before or during menstruation without any identifiable cause in the reproductive organs. It typically starts within the first few years of menstruation and may improve with age or after childbirth. The pain is directly related to the menstrual cycle and is caused by excess prostaglandin production.

Secondary dysmenorrhea results from an underlying medical condition affecting the reproductive organs. Common causes include endometriosis, adenomyosis, uterine fibroids, pelvic inflammatory disease, cervical stenosis, and ovarian cysts. This type often starts later in reproductive life and may be accompanied by other symptoms such as heavy bleeding, pain during intercourse, or pain between periods.

Understanding the difference matters:

While primary dysmenorrhea responds well to over-the-counter pain relievers and lifestyle measures, secondary dysmenorrhea often requires treatment of the underlying condition. If your menstrual pain is new, worsening, or doesn't respond to typical treatments, it's important to consult a healthcare provider to rule out secondary causes.

What Are the Symptoms of Menstrual Cramps?

Common symptoms of menstrual cramps include throbbing or cramping pain in the lower abdomen, pain radiating to the lower back and thighs, nausea, diarrhea, headache, dizziness, and fatigue. Symptoms typically begin 1-2 days before menstruation and are worst during the first 1-2 days of bleeding.

Menstrual cramp symptoms can vary significantly from person to person, both in type and intensity. Some women experience only mild discomfort that barely disrupts their day, while others face severe pain that makes normal activities impossible. Understanding the full range of symptoms can help you better communicate with healthcare providers and find appropriate treatment.

The primary symptom is pain in the lower abdomen, which most women describe as a cramping, throbbing, or aching sensation. This pain is often felt as a pressing or squeezing discomfort centered below the navel. Many women note that the pain comes in waves, intensifying for several minutes before temporarily subsiding. The cramping quality reflects the underlying cause: uterine muscle contractions designed to expel the uterine lining.

The pain frequently doesn't stay localized to the abdomen. Radiation to the lower back is extremely common, with many women experiencing dull, constant back pain alongside abdominal cramping. The inner thighs and groin area may also ache, as the nerves in the pelvic region are interconnected. Some women find the back pain more bothersome than the abdominal cramps.

  • Lower abdominal cramping: The hallmark symptom, ranging from mild to severe
  • Lower back pain: Often a constant, dull ache that accompanies cramps
  • Pain radiating to thighs: Caused by shared nerve pathways in the pelvis
  • Nausea and vomiting: Related to high prostaglandin levels affecting the digestive system
  • Diarrhea or loose stools: Prostaglandins also stimulate intestinal contractions
  • Headache: Often related to hormonal fluctuations
  • Dizziness and lightheadedness: May occur during severe pain episodes
  • Fatigue and weakness: The body's response to pain and hormonal changes

When Symptoms Are Most Severe

Most women experience their worst symptoms during the first one to two days of menstruation. This timing corresponds to when prostaglandin levels are highest. The pain often begins several hours before bleeding starts and peaks within the first 24 to 48 hours. For many, symptoms gradually improve as menstruation continues, with significant relief by days three to four.

Some women notice symptoms beginning even earlier, experiencing mild cramping or bloating one to two days before their period starts. This premenstrual discomfort is often distinct from the more intense cramping that occurs once bleeding begins. Tracking your symptoms throughout your cycle can help identify patterns and optimize timing for preventive treatment.

Menstrual cramp severity levels and typical impact
Severity Level Pain Description Impact on Daily Life Treatment Approach
Mild Dull ache, manageable discomfort Minimal interference with activities Heat therapy, gentle exercise
Moderate Noticeable cramping, some back pain May need to reduce some activities OTC pain relievers, heat therapy
Severe Intense cramping, nausea, unable to focus Missing work/school, bed rest needed Prescription medications, hormonal therapy
Disabling Excruciating pain, vomiting, fainting Complete inability to function Specialist evaluation, investigate secondary causes

What Causes Menstrual Cramps?

Menstrual cramps are primarily caused by prostaglandins, hormone-like chemicals that trigger uterine contractions to shed the uterine lining. Higher prostaglandin levels lead to stronger, more painful contractions. Secondary causes include endometriosis, adenomyosis, uterine fibroids, and pelvic inflammatory disease.

Understanding what causes menstrual cramps helps explain why certain treatments work and can guide you toward the most effective relief strategies. The pain of primary dysmenorrhea results from a complex interplay of hormones, muscle contractions, and blood flow changes that occur during menstruation.

At the heart of menstrual pain are prostaglandins, hormone-like substances produced by the uterine lining (endometrium). As hormone levels drop just before menstruation begins, cells in the endometrium release prostaglandins. These chemicals serve a crucial purpose: they cause the uterine muscle to contract, helping expel the uterine lining during your period. However, when prostaglandin levels are higher than normal, the contractions become more powerful, frequent, and painful.

The connection between prostaglandins and pain severity has been well established through research. Women with severe menstrual cramps have been shown to have significantly higher prostaglandin levels in their menstrual fluid compared to women with mild or no cramping. This explains why anti-prostaglandin medications like ibuprofen and naproxen are so effective for menstrual pain – they work by reducing prostaglandin production.

During menstruation, the intense uterine contractions can temporarily cut off blood supply to the uterine muscle. This ischemia (reduced blood flow) causes pain similar to the mechanism behind heart attack or leg cramp pain. When the muscle doesn't receive adequate oxygen, it triggers pain signals. Heat therapy works partly by improving blood flow to the area, counteracting this ischemic pain.

Risk Factors for Severe Menstrual Cramps

While any menstruating person can experience cramps, certain factors increase the likelihood of more severe pain. Research has identified several risk factors that correlate with increased menstrual pain intensity.

  • Early menarche: Starting periods before age 11 is associated with more severe cramps
  • Heavy menstrual flow: Heavier and longer periods tend to be more painful
  • Irregular menstrual cycles: Unpredictable cycles are linked to increased pain
  • Smoking: Nicotine affects blood flow and may increase prostaglandin sensitivity
  • Family history: If your mother or sisters have severe cramps, you're more likely to as well
  • Nulliparity: Never having given birth (though cramps often improve after childbirth)
  • Obesity: Higher body weight is associated with increased menstrual pain
  • Stress and anxiety: Psychological factors can amplify pain perception

Secondary Causes of Menstrual Pain

When menstrual pain is caused by an underlying condition, it's called secondary dysmenorrhea. These conditions affect the reproductive organs and often cause progressively worsening pain over time.

Endometriosis occurs when tissue similar to the uterine lining grows outside the uterus, commonly on the ovaries, fallopian tubes, and pelvic lining. This tissue responds to hormonal changes just like the uterine lining, bleeding during menstruation but with no way to exit the body. This causes inflammation, scarring, and often severe pain.

Adenomyosis is similar but involves the endometrial tissue growing into the muscular wall of the uterus itself. This causes the uterus to enlarge and can result in heavy, painful periods. Adenomyosis is more common in women over 30 who have had children.

Uterine fibroids are noncancerous growths in the uterine wall. While many fibroids cause no symptoms, larger ones or those in certain locations can cause heavy bleeding and painful cramps. The pain is often related to the fibroid's size and position.

When to suspect secondary dysmenorrhea:

Consider seeking evaluation if your cramps began after age 25, have progressively worsened over time, occur throughout your cycle (not just during menstruation), are accompanied by very heavy bleeding, or don't respond to over-the-counter treatments. These patterns may suggest an underlying condition requiring specific treatment.

What Can I Do Myself to Relieve Menstrual Cramps?

Effective self-care for menstrual cramps includes taking NSAIDs like ibuprofen or naproxen early, applying heat to the abdomen or lower back, gentle exercise like walking or yoga, staying hydrated, and getting adequate rest. Combining multiple approaches often provides the best relief.

Many women can effectively manage menstrual cramps with home remedies and over-the-counter treatments. The key is knowing which approaches have scientific support and how to use them most effectively. A combination of different strategies typically works better than relying on just one method.

Over-the-Counter Pain Medications

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most effective over-the-counter medications for menstrual cramps because they directly address the underlying cause: excess prostaglandin production. Ibuprofen (brand names include Advil, Motrin) and naproxen (Aleve) are the most commonly used NSAIDs for menstrual pain.

The timing of when you take these medications matters significantly. Taking an NSAID at the first sign of symptoms – ideally before severe pain develops – prevents the buildup of prostaglandins. Once prostaglandins have already been produced and pain is severe, medication is less effective. Many women benefit from starting NSAIDs one to two days before their period is expected to begin.

Standard dosing for ibuprofen is 400-600mg every 4-6 hours, with a maximum of 1,200mg in 24 hours for self-treatment. Naproxen dosing is typically 250-500mg every 8-12 hours. Always take these medications with food to reduce the risk of stomach irritation, and follow package directions carefully.

If NSAIDs aren't suitable for you (due to stomach sensitivity, kidney issues, or other contraindications), acetaminophen (paracetamol, Tylenol) can help with pain relief, though it doesn't reduce prostaglandin production and is generally less effective for menstrual cramps specifically.

Heat Therapy

Applying heat to the lower abdomen or lower back is one of the oldest remedies for menstrual cramps, and research confirms its effectiveness. Studies have shown that heat therapy can be as effective as ibuprofen for pain relief. Heat works by relaxing the contracting uterine muscles, improving blood flow to the area, and reducing the perception of pain.

You can use a heating pad, hot water bottle, heated wheat bag, or adhesive heat wraps. The temperature should be comfortably warm (around 104°F/40°C) but not hot enough to burn skin. Apply heat for 15-20 minutes at a time, and you can repeat as needed throughout the day.

Taking a warm bath or shower can provide similar benefits while also helping you relax overall. Some women find that alternating between heat application and gentle movement provides the best results.

Physical Activity and Exercise

While exercise might be the last thing you feel like doing during painful cramps, gentle physical activity can actually help reduce symptoms. Exercise releases endorphins – the body's natural painkillers – and improves blood circulation throughout the body, including to the pelvic area.

During acute cramping, low-intensity activities work best: a gentle walk, stretching, yoga designed for menstruation, or swimming. More vigorous exercise may be better reserved for the days when symptoms are milder. Regular exercise throughout your cycle (not just during menstruation) can help reduce the overall severity of menstrual pain over time.

Dietary and Lifestyle Approaches

Staying well-hydrated can help reduce bloating and may ease cramping. Warm beverages like herbal teas (chamomile, ginger, or peppermint) can provide comfort and mild relief. Some women find that reducing salt intake before their period helps minimize water retention and associated discomfort.

Getting adequate sleep is important, as fatigue can worsen pain perception. Try to maintain your regular sleep schedule during your period. Some women find that lying in a comfortable position with a pillow under the knees helps reduce abdominal pressure and pain.

Combining treatments for better relief:

Research suggests that combining approaches – such as taking an NSAID along with applying heat – provides better pain relief than either method alone. Don't hesitate to use multiple strategies together for optimal comfort during your period.

When Should You See a Doctor for Menstrual Cramps?

See a doctor if over-the-counter pain relievers don't provide adequate relief, if your cramps suddenly become more severe or change character, if you experience pain between periods, if cramps are accompanied by heavy bleeding soaking through pads hourly, or if pain significantly interferes with your daily life.

While menstrual cramps are common and often manageable at home, certain signs indicate you should seek medical evaluation. Knowing when to consult a healthcare provider ensures you don't overlook conditions that require specific treatment.

The most important reason to seek care is inadequate relief from standard treatments. If you're taking appropriate doses of NSAIDs as directed and still experiencing significant pain that interferes with your daily activities, this suggests either that you have an underlying condition or that you may benefit from prescription-strength treatments.

Changes in your menstrual pain pattern warrant attention. If your cramps suddenly become more severe than usual, if they start occurring at different times in your cycle, or if pain that previously was manageable becomes debilitating, these changes could indicate a developing condition like endometriosis or fibroids.

Pain that occurs outside of menstruation is particularly important to investigate. Primary dysmenorrhea causes pain only around the time of your period. Pain during ovulation, pain with intercourse, or chronic pelvic pain throughout the month suggests a secondary cause that needs evaluation.

  • Over-the-counter pain relievers don't provide adequate relief
  • Your menstrual cramps suddenly become more severe
  • You develop menstrual cramps for the first time after age 25
  • Pain progressively worsens with each cycle
  • You experience pain between menstrual periods
  • Cramps are accompanied by fever
  • Heavy bleeding that soaks through a pad or tampon every hour for several hours
  • Pain significantly interferes with work, school, or daily activities
  • You have symptoms of possible pregnancy (missed period, then severe cramping)
🚨 Seek immediate medical care if:
  • You have severe pelvic pain with fever
  • You experience sudden, severe pain that's different from usual cramps
  • You feel faint, dizzy, or have symptoms of shock (rapid heartbeat, cold sweats)
  • You might be pregnant and have severe cramping or bleeding

These symptoms could indicate a medical emergency such as an ectopic pregnancy, ovarian torsion, or severe infection. Find your emergency number →

How Are Menstrual Cramps Treated?

Medical treatment for menstrual cramps includes prescription-strength NSAIDs, hormonal contraceptives (pills, patches, IUDs, implants), and for severe secondary dysmenorrhea, treatment of underlying conditions. Hormonal birth control is highly effective, reducing pain by 70-80% in many women by preventing ovulation and thinning the uterine lining.

When over-the-counter treatments aren't sufficient, several medical options can provide significant relief. Your healthcare provider will consider your symptoms, reproductive plans, and any underlying conditions when recommending treatment.

Prescription Pain Medications

Prescription-strength NSAIDs, such as mefenamic acid (Ponstel) or higher doses of naproxen, may be recommended when over-the-counter doses aren't effective. These medications work through the same mechanism – reducing prostaglandin production – but at higher therapeutic levels. Your doctor may also prescribe other pain medications depending on your specific situation.

Hormonal Contraceptives

Hormonal birth control is one of the most effective treatments for menstrual cramps, often reducing pain by 70-80% or more. These methods work by preventing ovulation and thinning the uterine lining, which reduces the amount of prostaglandins produced. Options include:

Combined hormonal contraceptives (birth control pills, patches, or vaginal rings) contain both estrogen and progestin. They can be used cyclically with monthly periods or continuously to reduce or eliminate periods entirely. Many women notice significant improvement within 2-3 cycles.

Progestin-only methods include the hormonal IUD (Mirena, Liletta, Kyleena), the contraceptive implant (Nexplanon), and progestin-only pills. The hormonal IUD is particularly effective because it delivers hormones directly to the uterus, often reducing or stopping periods while having fewer systemic side effects.

The hormonal IUD deserves special mention as it's one of the most effective treatments for heavy, painful periods. Many users experience dramatically lighter periods or no periods at all, along with significantly reduced cramping. It's also long-acting, providing protection for 3-8 years depending on the brand.

TENS (Transcutaneous Electrical Nerve Stimulation)

TENS is a pain management technique that uses low-voltage electrical currents to stimulate nerves under the skin. Small electrodes are placed on the abdomen, and the device delivers mild electrical impulses that interfere with pain signals traveling to the brain. Some women find TENS helpful for menstrual cramps, and it's available as a non-medication option. Special menstrual TENS devices are now available for home use.

Treatment for Secondary Dysmenorrhea

If your cramps are caused by an underlying condition, treatment focuses on addressing that condition. For endometriosis, options include hormonal suppression therapy, GnRH agonists, or surgical removal of endometrial tissue. Fibroids may be treated with medications to shrink them or surgical procedures to remove them. Adenomyosis treatment typically involves hormonal therapy or, in severe cases, hysterectomy.

A note about fertility and treatment:

Many women worry that hormonal treatments might affect their future fertility. Hormonal contraceptives are reversible – fertility typically returns within a few months of stopping them. If you're trying to conceive, work with your healthcare provider to find alternative pain management strategies that are compatible with your goals.

What Happens in the Body During Menstrual Cramps?

During menstruation, the uterus contracts to expel its lining. These contractions are triggered by prostaglandins released from the endometrium. Higher prostaglandin levels cause stronger, more painful contractions and may also affect blood flow to the uterus, causing ischemic pain similar to that of muscle cramps.

Understanding the physiological processes behind menstrual cramps can help explain why certain treatments work and why pain varies so much between individuals. The menstrual cycle involves complex hormonal interactions that prepare the body for potential pregnancy each month.

Each menstrual cycle begins with the pituitary gland releasing follicle-stimulating hormone (FSH), which stimulates the ovaries to develop follicles containing eggs. The growing follicles produce estrogen, which causes the uterine lining (endometrium) to thicken in preparation for a potential fertilized egg. At mid-cycle, a surge of luteinizing hormone (LH) triggers ovulation – the release of an egg from the ovary.

After ovulation, the empty follicle becomes the corpus luteum, which produces progesterone. Progesterone further prepares the uterine lining for implantation. If pregnancy doesn't occur, the corpus luteum degenerates, progesterone and estrogen levels drop sharply, and the endometrium begins to break down.

The dropping hormone levels trigger the release of prostaglandins from the cells of the endometrium. Prostaglandins are fatty acid derivatives that act like hormones in certain situations. In menstruation, they serve to:

  • Trigger uterine muscle contractions to expel the uterine lining
  • Constrict blood vessels in the uterus to control bleeding
  • Stimulate inflammation as part of the shedding process

While these processes are necessary for menstruation to occur, excessive prostaglandin production leads to the painful symptoms of dysmenorrhea. The strong uterine contractions can temporarily compress blood vessels, reducing blood flow to the uterine muscle. This ischemia – lack of adequate blood supply – causes pain through the same mechanism as a muscle cramp or angina. When oxygen delivery is restored as the muscle relaxes, the pain temporarily subsides.

Prostaglandins also enter the bloodstream and can affect other organ systems. This explains why many women experience symptoms beyond pelvic pain: prostaglandins in the digestive tract cause nausea, diarrhea, and abdominal cramping; in the brain, they can contribute to headaches; and they can cause general symptoms like fatigue and feeling unwell.

Why Some Women Have More Pain

Research has shown that women with severe dysmenorrhea have significantly higher concentrations of prostaglandins in their menstrual fluid compared to women with mild or no pain. The reasons for these individual differences aren't fully understood but likely involve genetic factors affecting prostaglandin production and metabolism, as well as sensitivity to prostaglandins' effects.

Interestingly, menstrual cramps often improve with age and especially after childbirth. This may be related to changes in the uterus after pregnancy and delivery, including stretching of the cervix and alterations in nerve pathways. Some researchers theorize that pregnancy "resets" certain aspects of uterine function.

Can You Prevent Menstrual Cramps?

While menstrual cramps can't always be prevented entirely, regular exercise, maintaining a healthy weight, reducing stress, avoiding smoking, and taking NSAIDs preventively before symptoms begin can all help reduce their severity. Hormonal contraceptives can prevent cramps for many women.

Prevention strategies for menstrual cramps focus on lifestyle factors that may reduce prostaglandin production or the body's response to them, as well as timing treatments to prevent pain from developing in the first place.

Regular physical activity throughout your menstrual cycle (not just during your period) has been shown to reduce the severity of menstrual cramps. Exercise improves circulation, releases endorphins, and may help regulate hormones. Aim for at least 150 minutes of moderate activity per week. Both aerobic exercise and gentle activities like yoga have shown benefits.

Maintaining a healthy weight is associated with less severe menstrual pain. Excess body fat can affect hormone levels and inflammation, potentially increasing cramping. If you're overweight, even modest weight loss may help reduce symptoms.

Not smoking is important for many health reasons, including menstrual health. Smoking is associated with more severe menstrual cramps, possibly because nicotine constricts blood vessels and may affect prostaglandin metabolism.

Stress management can help, as psychological stress is associated with increased menstrual pain. Techniques like mindfulness, deep breathing, adequate sleep, and regular relaxation can help manage both stress and pain perception.

Preemptive pain medication is a practical prevention strategy for many women. Taking an NSAID one to two days before your period is expected to begin can prevent the buildup of prostaglandins and reduce the severity of cramps when they do occur. This approach is particularly effective for women with predictable cycles.

Some dietary factors may play a role, though evidence is less strong. Some studies suggest that omega-3 fatty acids (found in fatty fish, flaxseed, and walnuts) may help reduce inflammation and prostaglandin production. Reducing caffeine and alcohol around the time of menstruation may help some women, though this varies individually.

Frequently Asked Questions About Menstrual Cramps

Medical References and Sources

This article is based on current medical research and international guidelines. All claims are supported by scientific evidence from peer-reviewed sources.

  1. Cochrane Database of Systematic Reviews (2024). "Nonsteroidal anti-inflammatory drugs for dysmenorrhoea." https://doi.org/10.1002/14651858.CD001751.pub4 Systematic review of NSAIDs for menstrual pain. Evidence level: 1A
  2. American College of Obstetricians and Gynecologists (ACOG) (2023). "Dysmenorrhea and Endometriosis in the Adolescent." ACOG Committee Opinion. ACOG Clinical Guidelines Clinical practice guidelines for dysmenorrhea management.
  3. World Health Organization (WHO) (2022). "WHO Guideline on Self-Care Interventions for Health and Well-Being." WHO Publications International guidance on self-care for menstrual health.
  4. FIGO (International Federation of Gynecology and Obstetrics) (2023). "FIGO Recommendations on the Management of Endometriosis." International guidelines for endometriosis management.
  5. Armour M, et al. (2019). "The Effectiveness of Self-Care and Lifestyle Interventions in Primary Dysmenorrhea: A Systematic Review and Meta-Analysis." BMC Complementary and Alternative Medicine. 19(1):22. Evidence for lifestyle interventions including heat therapy and exercise.
  6. Burnett M, Lemyre M. (2017). "Primary Dysmenorrhea Consensus Guideline." Journal of Obstetrics and Gynaecology Canada. 39(7):585-595. Canadian clinical practice guidelines for primary dysmenorrhea.

Evidence grading: This article uses the GRADE framework (Grading of Recommendations Assessment, Development and Evaluation) for evidence-based medicine. Evidence level 1A represents the highest quality of evidence, based on systematic reviews of randomized controlled trials.

⚕️

iMedic Medical Editorial Team

Specialists in gynecology, reproductive medicine, and women's health

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