Theophylline and Zileuton: Drug Interaction Guide

Quick answer: This combination requires caution. Theophylline and Zileuton can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Theophylline interacts with Zileuton

Zileuton inhibits CYP1A2-mediated theophylline metabolism, increasing theophylline exposure and the risk of dose-related neurologic and cardiac toxicity.

What you should do

Reduce theophylline when zileuton is initiated and monitor serum concentrations and clinical toxicity. Reassess the dose if zileuton is discontinued.

Key facts

Severity

Moderate — caution required

Mechanism

Zileuton inhibits CYP1A2-mediated theophylline metabolism, increasing theophylline exposure and the risk of dose-related...

Action

Reduce theophylline when zileuton is initiated and monitor serum concentrations and clinical toxicity. Reassess the dose...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Theophylline and Zileuton together?

With caution. Reduce theophylline when zileuton is initiated and monitor serum concentrations and clinical toxicity. Reassess the dose if zileuton is discontinued.

What is the severity of this interaction?

The interaction between Theophylline and Zileuton is classified as Moderate — caution required. Zileuton inhibits CYP1A2-mediated theophylline metabolism, increasing theophylline exposure and the risk of dose-related neurologic and cardiac toxicity.

What should I do if I'm prescribed both?

Reduce theophylline when zileuton is initiated and monitor serum concentrations and clinical toxicity. Reassess the dose if zileuton is discontinued. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.