Warfarin and Zileuton: Drug Interaction Guide

Quick answer: This combination requires caution. Warfarin and Zileuton can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Warfarin interacts with Zileuton

Zileuton can increase warfarin exposure, likely through inhibition of hepatic metabolism including CYP pathways. This may increase prothrombin time and bleeding risk.

What you should do

Check INR after zileuton initiation and after dose changes. Adjust warfarin dose based on INR and bleeding assessment.

Key facts

Severity

Moderate — caution required

Mechanism

Zileuton can increase warfarin exposure, likely through inhibition of hepatic metabolism including CYP pathways. This ma...

Action

Check INR after zileuton initiation and after dose changes. Adjust warfarin dose based on INR and bleeding assessment.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Warfarin and Zileuton together?

With caution. Check INR after zileuton initiation and after dose changes. Adjust warfarin dose based on INR and bleeding assessment.

What is the severity of this interaction?

The interaction between Warfarin and Zileuton is classified as Moderate — caution required. Zileuton can increase warfarin exposure, likely through inhibition of hepatic metabolism including CYP pathways. This may increase prothrombin time and bleeding risk.

What should I do if I'm prescribed both?

Check INR after zileuton initiation and after dose changes. Adjust warfarin dose based on INR and bleeding assessment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.