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Statin and Grapefruit Juice: Drug Interaction Guide

Quick answer: This combination requires caution. Statin and Grapefruit Juice can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Statin interacts with Grapefruit Juice

Grapefruit inhibits CYP3A4 — increases atorvastatin/simvastatin levels and myopathy risk.

What you should do

Avoid grapefruit juice with simvastatin and lovastatin. Atorvastatin: limit to 1 small glass.

Key facts

Severity

Moderate — caution required

Mechanism

Grapefruit inhibits CYP3A4 — increases atorvastatin/simvastatin levels and myopathy risk.

Action

Avoid grapefruit juice with simvastatin and lovastatin. Atorvastatin: limit to 1 small glass.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Statin and Grapefruit Juice together?

With caution. Avoid grapefruit juice with simvastatin and lovastatin. Atorvastatin: limit to 1 small glass.

What is the severity of this interaction?

The interaction between Statin and Grapefruit Juice is classified as Moderate — caution required. Grapefruit inhibits CYP3A4 — increases atorvastatin/simvastatin levels and myopathy risk.

What should I do if I'm prescribed both?

Avoid grapefruit juice with simvastatin and lovastatin. Atorvastatin: limit to 1 small glass. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.