Felodipine and Grapefruit Juice: Drug Interaction Guide

Quick answer: This combination requires caution. Felodipine and Grapefruit Juice can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Felodipine interacts with Grapefruit Juice

Grapefruit juice inhibits intestinal CYP3A4, increasing felodipine bioavailability. This can exaggerate vasodilation and cause hypotension, flushing, or edema.

What you should do

Advise patients to avoid grapefruit products while taking felodipine. Monitor blood pressure if exposure has occurred.

Key facts

Severity

Moderate — caution required

Mechanism

Grapefruit juice inhibits intestinal CYP3A4, increasing felodipine bioavailability. This can exaggerate vasodilation and...

Action

Advise patients to avoid grapefruit products while taking felodipine. Monitor blood pressure if exposure has occurred.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Felodipine and Grapefruit Juice together?

With caution. Advise patients to avoid grapefruit products while taking felodipine. Monitor blood pressure if exposure has occurred.

What is the severity of this interaction?

The interaction between Felodipine and Grapefruit Juice is classified as Moderate — caution required. Grapefruit juice inhibits intestinal CYP3A4, increasing felodipine bioavailability. This can exaggerate vasodilation and cause hypotension, flushing, or edema.

What should I do if I'm prescribed both?

Advise patients to avoid grapefruit products while taking felodipine. Monitor blood pressure if exposure has occurred. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.