Ritonavir and Sildenafil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ritonavir and Sildenafil unless specifically directed by your doctor.
How Ritonavir interacts with Sildenafil
Ritonavir is a potent CYP3A4 inhibitor that increases sildenafil exposure up to 11-fold, raising risk of severe hypotension, priapism, and visual disturbances.
What you should do
For erectile dysfunction, limit sildenafil to 25 mg every 48 hours. For pulmonary hypertension, sildenafil is contraindicated with ritonavir.
Key facts
Severity
Major — avoid combination
Mechanism
Ritonavir is a potent CYP3A4 inhibitor that increases sildenafil exposure up to 11-fold, raising risk of severe hypotens...
Action
For erectile dysfunction, limit sildenafil to 25 mg every 48 hours. For pulmonary hypertension, sildenafil is contraindi...
Frequently asked questions
Can I take Ritonavir and Sildenafil together?
No — this combination should generally be avoided. For erectile dysfunction, limit sildenafil to 25 mg every 48 hours. For pulmonary hypertension, sildenafil is contraindicated with ritonavir.
What is the severity of this interaction?
The interaction between Ritonavir and Sildenafil is classified as Major — avoid combination. Ritonavir is a potent CYP3A4 inhibitor that increases sildenafil exposure up to 11-fold, raising risk of severe hypotension, priapism, and visual disturbances.
What should I do if I'm prescribed both?
For erectile dysfunction, limit sildenafil to 25 mg every 48 hours. For pulmonary hypertension, sildenafil is contraindicated with ritonavir. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.