Sildenafil and Sodium Nitrite: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Sildenafil and Sodium Nitrite unless specifically directed by your doctor.
How Sildenafil interacts with Sodium Nitrite
Both agents increase nitric oxide-cyclic guanosine monophosphate-mediated vasodilation, producing potentially profound hypotension.
What you should do
Do not co-administer. Use alternative treatment for angina or erectile dysfunction and observe required nitrate-free intervals.
Key facts
Severity
Major — avoid combination
Mechanism
Both agents increase nitric oxide-cyclic guanosine monophosphate-mediated vasodilation, producing potentially profound h...
Action
Do not co-administer. Use alternative treatment for angina or erectile dysfunction and observe required nitrate-free int...
Frequently asked questions
Can I take Sildenafil and Sodium Nitrite together?
No — this combination should generally be avoided. Do not co-administer. Use alternative treatment for angina or erectile dysfunction and observe required nitrate-free intervals.
What is the severity of this interaction?
The interaction between Sildenafil and Sodium Nitrite is classified as Major — avoid combination. Both agents increase nitric oxide-cyclic guanosine monophosphate-mediated vasodilation, producing potentially profound hypotension.
What should I do if I'm prescribed both?
Do not co-administer. Use alternative treatment for angina or erectile dysfunction and observe required nitrate-free intervals. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.