Ritonavir and Salmeterol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ritonavir and Salmeterol unless specifically directed by your doctor.
How Ritonavir interacts with Salmeterol
Ritonavir potently inhibits CYP3A4 metabolism of salmeterol, producing markedly elevated systemic levels with risk of QT prolongation, palpitations, and arrhythmia.
What you should do
Avoid combination; substitute formoterol-containing inhalers or short-acting beta agonists where possible.
Key facts
Severity
Major — avoid combination
Mechanism
Ritonavir potently inhibits CYP3A4 metabolism of salmeterol, producing markedly elevated systemic levels with risk of QT...
Action
Avoid combination; substitute formoterol-containing inhalers or short-acting beta agonists where possible.
Frequently asked questions
Can I take Ritonavir and Salmeterol together?
No — this combination should generally be avoided. Avoid combination; substitute formoterol-containing inhalers or short-acting beta agonists where possible.
What is the severity of this interaction?
The interaction between Ritonavir and Salmeterol is classified as Major — avoid combination. Ritonavir potently inhibits CYP3A4 metabolism of salmeterol, producing markedly elevated systemic levels with risk of QT prolongation, palpitations, and arrhythmia.
What should I do if I'm prescribed both?
Avoid combination; substitute formoterol-containing inhalers or short-acting beta agonists where possible. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.