Rifabutin and Voriconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Rifabutin and Voriconazole unless specifically directed by your doctor.
How Rifabutin interacts with Voriconazole
Rifabutin induces CYP enzymes and lowers voriconazole exposure, while voriconazole inhibits CYP3A4 and increases rifabutin exposure, risking antifungal failure and rifabutin toxicity.
What you should do
Avoid coadministration and choose an alternative antimycobacterial or antifungal regimen.
Key facts
Severity
Major — avoid combination
Mechanism
Rifabutin induces CYP enzymes and lowers voriconazole exposure, while voriconazole inhibits CYP3A4 and increases rifabut...
Action
Avoid coadministration and choose an alternative antimycobacterial or antifungal regimen.
Frequently asked questions
Can I take Rifabutin and Voriconazole together?
No — this combination should generally be avoided. Avoid coadministration and choose an alternative antimycobacterial or antifungal regimen.
What is the severity of this interaction?
The interaction between Rifabutin and Voriconazole is classified as Major — avoid combination. Rifabutin induces CYP enzymes and lowers voriconazole exposure, while voriconazole inhibits CYP3A4 and increases rifabutin exposure, risking antifungal failure and rifabutin toxicity.
What should I do if I'm prescribed both?
Avoid coadministration and choose an alternative antimycobacterial or antifungal regimen. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.