Ticagrelor and Voriconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ticagrelor and Voriconazole unless specifically directed by your doctor.
How Ticagrelor interacts with Voriconazole
Voriconazole strongly inhibits CYP3A4, which metabolizes ticagrelor. Increased ticagrelor exposure can substantially increase bleeding risk.
What you should do
Avoid co-prescribing. Use an alternative antifungal or consider an antiplatelet agent less affected by CYP3A4 inhibition after specialist review.
Key facts
Severity
Major — avoid combination
Mechanism
Voriconazole strongly inhibits CYP3A4, which metabolizes ticagrelor. Increased ticagrelor exposure can substantially inc...
Action
Avoid co-prescribing. Use an alternative antifungal or consider an antiplatelet agent less affected by CYP3A4 inhibition...
Frequently asked questions
Can I take Ticagrelor and Voriconazole together?
No — this combination should generally be avoided. Avoid co-prescribing. Use an alternative antifungal or consider an antiplatelet agent less affected by CYP3A4 inhibition after specialist review.
What is the severity of this interaction?
The interaction between Ticagrelor and Voriconazole is classified as Major — avoid combination. Voriconazole strongly inhibits CYP3A4, which metabolizes ticagrelor. Increased ticagrelor exposure can substantially increase bleeding risk.
What should I do if I'm prescribed both?
Avoid co-prescribing. Use an alternative antifungal or consider an antiplatelet agent less affected by CYP3A4 inhibition after specialist review. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.