Nivolumab and Tacrolimus: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Nivolumab and Tacrolimus unless specifically directed by your doctor.
How Nivolumab interacts with Tacrolimus
Nivolumab blocks PD-1 signaling and enhances T-cell immune activity, while tacrolimus suppresses calcineurin-dependent T-cell activation. In transplant recipients, PD-1 blockade can overcome immunosuppression and trigger graft rejection.
What you should do
Avoid unless benefits clearly outweigh risks and specialist transplant-oncology teams agree. Monitor closely for graft dysfunction and immune-related adverse events.
Key facts
Severity
Major — avoid combination
Mechanism
Nivolumab blocks PD-1 signaling and enhances T-cell immune activity, while tacrolimus suppresses calcineurin-dependent T...
Action
Avoid unless benefits clearly outweigh risks and specialist transplant-oncology teams agree. Monitor closely for graft d...
Frequently asked questions
Can I take Nivolumab and Tacrolimus together?
No — this combination should generally be avoided. Avoid unless benefits clearly outweigh risks and specialist transplant-oncology teams agree. Monitor closely for graft dysfunction and immune-related adverse events.
What is the severity of this interaction?
The interaction between Nivolumab and Tacrolimus is classified as Major — avoid combination. Nivolumab blocks PD-1 signaling and enhances T-cell immune activity, while tacrolimus suppresses calcineurin-dependent T-cell activation. In transplant recipients, PD-1 blockade can overcome immunosuppression and trigger graft rejection.
What should I do if I'm prescribed both?
Avoid unless benefits clearly outweigh risks and specialist transplant-oncology teams agree. Monitor closely for graft dysfunction and immune-related adverse events. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.