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Nitrates and Sildenafil: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Nitrates and Sildenafil unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Nitrates interacts with Sildenafil

Severe hypotension risk — both lower blood pressure dramatically.

What you should do

Absolute contraindication. Wait 24 hours after sildenafil before nitrates.

Key facts

Severity

Major — avoid combination

Mechanism

Severe hypotension risk — both lower blood pressure dramatically.

Action

Absolute contraindication. Wait 24 hours after sildenafil before nitrates.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Nitrates and Sildenafil together?

No — this combination should generally be avoided. Absolute contraindication. Wait 24 hours after sildenafil before nitrates.

What is the severity of this interaction?

The interaction between Nitrates and Sildenafil is classified as Major — avoid combination. Severe hypotension risk — both lower blood pressure dramatically.

What should I do if I'm prescribed both?

Absolute contraindication. Wait 24 hours after sildenafil before nitrates. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.