Phenelzine and Sumatriptan: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Phenelzine and Sumatriptan unless specifically directed by your doctor.
How Phenelzine interacts with Sumatriptan
Monoamine oxidase inhibition reduces sumatriptan metabolism and, together with serotonergic receptor effects, increases exposure and the risk of serious serotonergic or vasoconstrictive reactions.
What you should do
Do not coadminister sumatriptan during phenelzine treatment or within two weeks after stopping the monoamine oxidase inhibitor.
Key facts
Severity
Major — avoid combination
Mechanism
Monoamine oxidase inhibition reduces sumatriptan metabolism and, together with serotonergic receptor effects, increases ...
Action
Do not coadminister sumatriptan during phenelzine treatment or within two weeks after stopping the monoamine oxidase inh...
Frequently asked questions
Can I take Phenelzine and Sumatriptan together?
No — this combination should generally be avoided. Do not coadminister sumatriptan during phenelzine treatment or within two weeks after stopping the monoamine oxidase inhibitor.
What is the severity of this interaction?
The interaction between Phenelzine and Sumatriptan is classified as Major — avoid combination. Monoamine oxidase inhibition reduces sumatriptan metabolism and, together with serotonergic receptor effects, increases exposure and the risk of serious serotonergic or vasoconstrictive reactions.
What should I do if I'm prescribed both?
Do not coadminister sumatriptan during phenelzine treatment or within two weeks after stopping the monoamine oxidase inhibitor. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.