Miconazole and Warfarin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Miconazole and Warfarin unless specifically directed by your doctor.
How Miconazole interacts with Warfarin
Even topical/oral-gel miconazole inhibits CYP2C9 and CYP3A4, markedly potentiating warfarin's anticoagulant effect and risking serious hemorrhage.
What you should do
Avoid miconazole (including oral gel and intravaginal preparations) in patients on warfarin. If used, monitor INR within 3-5 days and adjust warfarin dose accordingly.
Key facts
Severity
Major — avoid combination
Mechanism
Even topical/oral-gel miconazole inhibits CYP2C9 and CYP3A4, markedly potentiating warfarin's anticoagulant effect and r...
Action
Avoid miconazole (including oral gel and intravaginal preparations) in patients on warfarin. If used, monitor INR within...
Frequently asked questions
Can I take Miconazole and Warfarin together?
No — this combination should generally be avoided. Avoid miconazole (including oral gel and intravaginal preparations) in patients on warfarin. If used, monitor INR within 3-5 days and adjust warfarin dose accordingly.
What is the severity of this interaction?
The interaction between Miconazole and Warfarin is classified as Major — avoid combination. Even topical/oral-gel miconazole inhibits CYP2C9 and CYP3A4, markedly potentiating warfarin's anticoagulant effect and risking serious hemorrhage.
What should I do if I'm prescribed both?
Avoid miconazole (including oral gel and intravaginal preparations) in patients on warfarin. If used, monitor INR within 3-5 days and adjust warfarin dose accordingly. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.