Losartan and Nsaids: Drug Interaction Guide

Quick answer: This combination requires caution. Losartan and Nsaids can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Losartan interacts with Nsaids

NSAIDs inhibit renal prostaglandin synthesis, reducing afferent arteriolar vasodilation. Combined with angiotensin receptor blockade, this can reduce glomerular filtration and blunt antihypertensive effect.

What you should do

Use the lowest NSAID dose for the shortest duration and monitor blood pressure, renal function, and potassium. Avoid chronic NSAID use where possible.

Key facts

Severity

Moderate — caution required

Mechanism

NSAIDs inhibit renal prostaglandin synthesis, reducing afferent arteriolar vasodilation. Combined with angiotensin recep...

Action

Use the lowest NSAID dose for the shortest duration and monitor blood pressure, renal function, and potassium. Avoid chr...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Losartan and Nsaids together?

With caution. Use the lowest NSAID dose for the shortest duration and monitor blood pressure, renal function, and potassium. Avoid chronic NSAID use where possible.

What is the severity of this interaction?

The interaction between Losartan and Nsaids is classified as Moderate — caution required. NSAIDs inhibit renal prostaglandin synthesis, reducing afferent arteriolar vasodilation. Combined with angiotensin receptor blockade, this can reduce glomerular filtration and blunt antihypertensive effect.

What should I do if I'm prescribed both?

Use the lowest NSAID dose for the shortest duration and monitor blood pressure, renal function, and potassium. Avoid chronic NSAID use where possible. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.