Linezolid and Serotonergic Agent: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Linezolid and Serotonergic Agent unless specifically directed by your doctor.
How Linezolid interacts with Serotonergic Agent
Linezolid is a reversible non-selective MAO inhibitor; combination with SSRIs, SNRIs, triptans, or tramadol increases synaptic serotonin and risk of serotonin syndrome.
What you should do
Avoid combination. Wash out serotonergic agents before linezolid (5 weeks for fluoxetine, 2 weeks for MAOIs, ≥24 hours for short-acting agents) where clinically feasible.
Key facts
Severity
Major — avoid combination
Mechanism
Linezolid is a reversible non-selective MAO inhibitor; combination with SSRIs, SNRIs, triptans, or tramadol increases sy...
Action
Avoid combination. Wash out serotonergic agents before linezolid (5 weeks for fluoxetine, 2 weeks for MAOIs, ≥24 hours f...
Frequently asked questions
Can I take Linezolid and Serotonergic Agent together?
No — this combination should generally be avoided. Avoid combination. Wash out serotonergic agents before linezolid (5 weeks for fluoxetine, 2 weeks for MAOIs, ≥24 hours for short-acting agents) where clinically feasible.
What is the severity of this interaction?
The interaction between Linezolid and Serotonergic Agent is classified as Major — avoid combination. Linezolid is a reversible non-selective MAO inhibitor; combination with SSRIs, SNRIs, triptans, or tramadol increases synaptic serotonin and risk of serotonin syndrome.
What should I do if I'm prescribed both?
Avoid combination. Wash out serotonergic agents before linezolid (5 weeks for fluoxetine, 2 weeks for MAOIs, ≥24 hours for short-acting agents) where clinically feasible. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.