Ketoconazole and Zolpidem: Drug Interaction Guide

Quick answer: This combination requires caution. Ketoconazole and Zolpidem can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Ketoconazole interacts with Zolpidem

Ketoconazole inhibits CYP3A4, increasing zolpidem exposure and sedative effects.

What you should do

Use a lower zolpidem dose or select an alternative hypnotic. Monitor for excessive next-day sedation, confusion, and falls.

Key facts

Severity

Moderate — caution required

Mechanism

Ketoconazole inhibits CYP3A4, increasing zolpidem exposure and sedative effects.

Action

Use a lower zolpidem dose or select an alternative hypnotic. Monitor for excessive next-day sedation, confusion, and fal...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ketoconazole and Zolpidem together?

With caution. Use a lower zolpidem dose or select an alternative hypnotic. Monitor for excessive next-day sedation, confusion, and falls.

What is the severity of this interaction?

The interaction between Ketoconazole and Zolpidem is classified as Moderate — caution required. Ketoconazole inhibits CYP3A4, increasing zolpidem exposure and sedative effects.

What should I do if I'm prescribed both?

Use a lower zolpidem dose or select an alternative hypnotic. Monitor for excessive next-day sedation, confusion, and falls. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.