Ketoconazole and Tofacitinib: Drug Interaction Guide

Quick answer: This combination requires caution. Ketoconazole and Tofacitinib can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Ketoconazole interacts with Tofacitinib

Ketoconazole strongly inhibits CYP3A4, increasing tofacitinib exposure and risk of infection, cytopenias, and other dose-related toxicity.

What you should do

Reduce tofacitinib dose according to product guidance or use an alternative antifungal; monitor for infection and blood count abnormalities.

Key facts

Severity

Moderate — caution required

Mechanism

Ketoconazole strongly inhibits CYP3A4, increasing tofacitinib exposure and risk of infection, cytopenias, and other dose...

Action

Reduce tofacitinib dose according to product guidance or use an alternative antifungal; monitor for infection and blood ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ketoconazole and Tofacitinib together?

With caution. Reduce tofacitinib dose according to product guidance or use an alternative antifungal; monitor for infection and blood count abnormalities.

What is the severity of this interaction?

The interaction between Ketoconazole and Tofacitinib is classified as Moderate — caution required. Ketoconazole strongly inhibits CYP3A4, increasing tofacitinib exposure and risk of infection, cytopenias, and other dose-related toxicity.

What should I do if I'm prescribed both?

Reduce tofacitinib dose according to product guidance or use an alternative antifungal; monitor for infection and blood count abnormalities. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.