Itraconazole and Omeprazole: Drug Interaction Guide
Quick answer: This combination requires caution. Itraconazole and Omeprazole can be used together with adjustments and monitoring.
How Itraconazole interacts with Omeprazole
Omeprazole raises gastric pH and substantially reduces dissolution and absorption of itraconazole capsules.
What you should do
Prefer itraconazole oral solution or an alternative antifungal; if capsules are required, consider an acidic beverage and assess clinical response.
Key facts
Severity
Moderate — caution required
Mechanism
Omeprazole raises gastric pH and substantially reduces dissolution and absorption of itraconazole capsules.
Action
Prefer itraconazole oral solution or an alternative antifungal; if capsules are required, consider an acidic beverage an...
Frequently asked questions
Can I take Itraconazole and Omeprazole together?
With caution. Prefer itraconazole oral solution or an alternative antifungal; if capsules are required, consider an acidic beverage and assess clinical response.
What is the severity of this interaction?
The interaction between Itraconazole and Omeprazole is classified as Moderate — caution required. Omeprazole raises gastric pH and substantially reduces dissolution and absorption of itraconazole capsules.
What should I do if I'm prescribed both?
Prefer itraconazole oral solution or an alternative antifungal; if capsules are required, consider an acidic beverage and assess clinical response. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.