Omeprazole and Pazopanib: Drug Interaction Guide

Quick answer: This combination requires caution. Omeprazole and Pazopanib can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Omeprazole interacts with Pazopanib

Omeprazole raises gastric pH, reducing dissolution and absorption of the pH-dependent tyrosine-kinase inhibitor pazopanib and potentially decreasing antitumour exposure.

What you should do

Avoid proton-pump inhibitors when possible during pazopanib therapy. If acid relief is essential, consider a short-acting antacid separated from pazopanib according to specialist guidance.

Key facts

Severity

Moderate — caution required

Mechanism

Omeprazole raises gastric pH, reducing dissolution and absorption of the pH-dependent tyrosine-kinase inhibitor pazopani...

Action

Avoid proton-pump inhibitors when possible during pazopanib therapy. If acid relief is essential, consider a short-actin...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Omeprazole and Pazopanib together?

With caution. Avoid proton-pump inhibitors when possible during pazopanib therapy. If acid relief is essential, consider a short-acting antacid separated from pazopanib according to specialist guidance.

What is the severity of this interaction?

The interaction between Omeprazole and Pazopanib is classified as Moderate — caution required. Omeprazole raises gastric pH, reducing dissolution and absorption of the pH-dependent tyrosine-kinase inhibitor pazopanib and potentially decreasing antitumour exposure.

What should I do if I'm prescribed both?

Avoid proton-pump inhibitors when possible during pazopanib therapy. If acid relief is essential, consider a short-acting antacid separated from pazopanib according to specialist guidance. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.