Isosorbide Dinitrate and Sildenafil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Isosorbide Dinitrate and Sildenafil unless specifically directed by your doctor.
How Isosorbide Dinitrate interacts with Sildenafil
Nitrate-mediated nitric oxide production and phosphodiesterase-5 inhibition synergistically increase cyclic GMP, causing potentially life-threatening hypotension.
What you should do
Do not coadminister. Ensure an adequate nitrate-free interval and seek specialist advice if antianginal therapy is required.
Key facts
Severity
Major — avoid combination
Mechanism
Nitrate-mediated nitric oxide production and phosphodiesterase-5 inhibition synergistically increase cyclic GMP, causing...
Action
Do not coadminister. Ensure an adequate nitrate-free interval and seek specialist advice if antianginal therapy is requi...
Frequently asked questions
Can I take Isosorbide Dinitrate and Sildenafil together?
No — this combination should generally be avoided. Do not coadminister. Ensure an adequate nitrate-free interval and seek specialist advice if antianginal therapy is required.
What is the severity of this interaction?
The interaction between Isosorbide Dinitrate and Sildenafil is classified as Major — avoid combination. Nitrate-mediated nitric oxide production and phosphodiesterase-5 inhibition synergistically increase cyclic GMP, causing potentially life-threatening hypotension.
What should I do if I'm prescribed both?
Do not coadminister. Ensure an adequate nitrate-free interval and seek specialist advice if antianginal therapy is required. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.