Indomethacin and Triamterene: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Indomethacin and Triamterene unless specifically directed by your doctor.
How Indomethacin interacts with Triamterene
NSAIDs reduce renal prostaglandin-dependent perfusion while triamterene blocks distal sodium channels, with the combination producing acute kidney injury and severe hyperkalaemia.
What you should do
Avoid this combination; if NSAID required with potassium-sparing diuretic, use shortest course and monitor creatinine and potassium within 3-7 days.
Key facts
Severity
Major — avoid combination
Mechanism
NSAIDs reduce renal prostaglandin-dependent perfusion while triamterene blocks distal sodium channels, with the combinat...
Action
Avoid this combination; if NSAID required with potassium-sparing diuretic, use shortest course and monitor creatinine an...
Frequently asked questions
Can I take Indomethacin and Triamterene together?
No — this combination should generally be avoided. Avoid this combination; if NSAID required with potassium-sparing diuretic, use shortest course and monitor creatinine and potassium within 3-7 days.
What is the severity of this interaction?
The interaction between Indomethacin and Triamterene is classified as Major — avoid combination. NSAIDs reduce renal prostaglandin-dependent perfusion while triamterene blocks distal sodium channels, with the combination producing acute kidney injury and severe hyperkalaemia.
What should I do if I'm prescribed both?
Avoid this combination; if NSAID required with potassium-sparing diuretic, use shortest course and monitor creatinine and potassium within 3-7 days. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.