Ibrutinib and Posaconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ibrutinib and Posaconazole unless specifically directed by your doctor.
How Ibrutinib interacts with Posaconazole
Posaconazole strongly inhibits CYP3A4, substantially increasing ibrutinib exposure and the risks of bleeding, arrhythmia, and other concentration-dependent toxicity.
What you should do
Avoid the combination when possible. If posaconazole is essential, interrupt or reduce ibrutinib according to its prescribing guidance and monitor closely for toxicity.
Key facts
Severity
Major — avoid combination
Mechanism
Posaconazole strongly inhibits CYP3A4, substantially increasing ibrutinib exposure and the risks of bleeding, arrhythmia...
Action
Avoid the combination when possible. If posaconazole is essential, interrupt or reduce ibrutinib according to its prescr...
Frequently asked questions
Can I take Ibrutinib and Posaconazole together?
No — this combination should generally be avoided. Avoid the combination when possible. If posaconazole is essential, interrupt or reduce ibrutinib according to its prescribing guidance and monitor closely for toxicity.
What is the severity of this interaction?
The interaction between Ibrutinib and Posaconazole is classified as Major — avoid combination. Posaconazole strongly inhibits CYP3A4, substantially increasing ibrutinib exposure and the risks of bleeding, arrhythmia, and other concentration-dependent toxicity.
What should I do if I'm prescribed both?
Avoid the combination when possible. If posaconazole is essential, interrupt or reduce ibrutinib according to its prescribing guidance and monitor closely for toxicity. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.