Ibrutinib and Itraconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ibrutinib and Itraconazole unless specifically directed by your doctor.
How Ibrutinib interacts with Itraconazole
Itraconazole strongly inhibits CYP3A4, markedly increasing ibrutinib exposure and the risk of bleeding, arrhythmias, and other toxicities.
What you should do
Avoid concomitant use when possible. Select an alternative antifungal or follow product-specific interruption and dose-reduction guidance.
Key facts
Severity
Major — avoid combination
Mechanism
Itraconazole strongly inhibits CYP3A4, markedly increasing ibrutinib exposure and the risk of bleeding, arrhythmias, and...
Action
Avoid concomitant use when possible. Select an alternative antifungal or follow product-specific interruption and dose-r...
Frequently asked questions
Can I take Ibrutinib and Itraconazole together?
No — this combination should generally be avoided. Avoid concomitant use when possible. Select an alternative antifungal or follow product-specific interruption and dose-reduction guidance.
What is the severity of this interaction?
The interaction between Ibrutinib and Itraconazole is classified as Major — avoid combination. Itraconazole strongly inhibits CYP3A4, markedly increasing ibrutinib exposure and the risk of bleeding, arrhythmias, and other toxicities.
What should I do if I'm prescribed both?
Avoid concomitant use when possible. Select an alternative antifungal or follow product-specific interruption and dose-reduction guidance. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.