Glycerol Trinitrate and Sildenafil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Glycerol Trinitrate and Sildenafil unless specifically directed by your doctor.
How Glycerol Trinitrate interacts with Sildenafil
Glycerol trinitrate increases nitric-oxide-mediated cyclic GMP production, while sildenafil prevents cyclic GMP degradation through PDE5 inhibition, causing profound vasodilation and hypotension.
What you should do
Concurrent use is contraindicated. Do not administer nitrates within the product-specific interval after sildenafil, and use non-nitrate management for angina during that period.
Key facts
Severity
Major — avoid combination
Mechanism
Glycerol trinitrate increases nitric-oxide-mediated cyclic GMP production, while sildenafil prevents cyclic GMP degradat...
Action
Concurrent use is contraindicated. Do not administer nitrates within the product-specific interval after sildenafil, and...
Frequently asked questions
Can I take Glycerol Trinitrate and Sildenafil together?
No — this combination should generally be avoided. Concurrent use is contraindicated. Do not administer nitrates within the product-specific interval after sildenafil, and use non-nitrate management for angina during that period.
What is the severity of this interaction?
The interaction between Glycerol Trinitrate and Sildenafil is classified as Major — avoid combination. Glycerol trinitrate increases nitric-oxide-mediated cyclic GMP production, while sildenafil prevents cyclic GMP degradation through PDE5 inhibition, causing profound vasodilation and hypotension.
What should I do if I'm prescribed both?
Concurrent use is contraindicated. Do not administer nitrates within the product-specific interval after sildenafil, and use non-nitrate management for angina during that period. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.