Gefitinib and Omeprazole: Drug Interaction Guide
Quick answer: This combination requires caution. Gefitinib and Omeprazole can be used together with adjustments and monitoring.
How Gefitinib interacts with Omeprazole
Omeprazole raises gastric pH, decreasing the pH-dependent solubility and absorption of gefitinib. Sustained acid suppression can substantially reduce gefitinib exposure and potentially compromise efficacy.
What you should do
Avoid proton-pump inhibitors during gefitinib therapy when possible. Use an appropriately separated short-acting antacid or specialist-approved alternative.
Key facts
Severity
Moderate — caution required
Mechanism
Omeprazole raises gastric pH, decreasing the pH-dependent solubility and absorption of gefitinib. Sustained acid suppres...
Action
Avoid proton-pump inhibitors during gefitinib therapy when possible. Use an appropriately separated short-acting antacid...
Frequently asked questions
Can I take Gefitinib and Omeprazole together?
With caution. Avoid proton-pump inhibitors during gefitinib therapy when possible. Use an appropriately separated short-acting antacid or specialist-approved alternative.
What is the severity of this interaction?
The interaction between Gefitinib and Omeprazole is classified as Moderate — caution required. Omeprazole raises gastric pH, decreasing the pH-dependent solubility and absorption of gefitinib. Sustained acid suppression can substantially reduce gefitinib exposure and potentially compromise efficacy.
What should I do if I'm prescribed both?
Avoid proton-pump inhibitors during gefitinib therapy when possible. Use an appropriately separated short-acting antacid or specialist-approved alternative. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.