Fluticasone Propionate and Ritonavir: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Fluticasone Propionate and Ritonavir unless specifically directed by your doctor.
How Fluticasone Propionate interacts with Ritonavir
Ritonavir strongly inhibits CYP3A4, markedly reducing fluticasone metabolism and causing systemic corticosteroid exposure, adrenal suppression, and Cushing syndrome.
What you should do
Avoid the combination unless no suitable alternative exists. Consider beclometasone and monitor for adrenal suppression if concurrent therapy cannot be avoided.
Key facts
Severity
Major — avoid combination
Mechanism
Ritonavir strongly inhibits CYP3A4, markedly reducing fluticasone metabolism and causing systemic corticosteroid exposur...
Action
Avoid the combination unless no suitable alternative exists. Consider beclometasone and monitor for adrenal suppression ...
Frequently asked questions
Can I take Fluticasone Propionate and Ritonavir together?
No — this combination should generally be avoided. Avoid the combination unless no suitable alternative exists. Consider beclometasone and monitor for adrenal suppression if concurrent therapy cannot be avoided.
What is the severity of this interaction?
The interaction between Fluticasone Propionate and Ritonavir is classified as Major — avoid combination. Ritonavir strongly inhibits CYP3A4, markedly reducing fluticasone metabolism and causing systemic corticosteroid exposure, adrenal suppression, and Cushing syndrome.
What should I do if I'm prescribed both?
Avoid the combination unless no suitable alternative exists. Consider beclometasone and monitor for adrenal suppression if concurrent therapy cannot be avoided. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.