Erythromycin and Theophylline: Drug Interaction Guide
Quick answer: This combination requires caution. Erythromycin and Theophylline can be used together with adjustments and monitoring.
How Erythromycin interacts with Theophylline
Erythromycin inhibits CYP3A4 metabolism of theophylline, raising serum concentrations and risk of nausea, tremor, and seizures.
What you should do
Monitor theophylline levels and reduce dose by 25% if signs of toxicity appear; consider azithromycin as an alternative.
Key facts
Severity
Moderate — caution required
Mechanism
Erythromycin inhibits CYP3A4 metabolism of theophylline, raising serum concentrations and risk of nausea, tremor, and se...
Action
Monitor theophylline levels and reduce dose by 25% if signs of toxicity appear; consider azithromycin as an alternative.
Frequently asked questions
Can I take Erythromycin and Theophylline together?
With caution. Monitor theophylline levels and reduce dose by 25% if signs of toxicity appear; consider azithromycin as an alternative.
What is the severity of this interaction?
The interaction between Erythromycin and Theophylline is classified as Moderate — caution required. Erythromycin inhibits CYP3A4 metabolism of theophylline, raising serum concentrations and risk of nausea, tremor, and seizures.
What should I do if I'm prescribed both?
Monitor theophylline levels and reduce dose by 25% if signs of toxicity appear; consider azithromycin as an alternative. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.