Eplerenone and Itraconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Eplerenone and Itraconazole unless specifically directed by your doctor.
How Eplerenone interacts with Itraconazole
Itraconazole strongly inhibits CYP3A4, substantially increasing eplerenone concentrations and hyperkalaemia risk.
What you should do
Avoid this combination. Use an alternative antifungal or select a different mineralocorticoid receptor antagonist strategy.
Key facts
Severity
Major — avoid combination
Mechanism
Itraconazole strongly inhibits CYP3A4, substantially increasing eplerenone concentrations and hyperkalaemia risk.
Action
Avoid this combination. Use an alternative antifungal or select a different mineralocorticoid receptor antagonist strate...
Frequently asked questions
Can I take Eplerenone and Itraconazole together?
No — this combination should generally be avoided. Avoid this combination. Use an alternative antifungal or select a different mineralocorticoid receptor antagonist strategy.
What is the severity of this interaction?
The interaction between Eplerenone and Itraconazole is classified as Major — avoid combination. Itraconazole strongly inhibits CYP3A4, substantially increasing eplerenone concentrations and hyperkalaemia risk.
What should I do if I'm prescribed both?
Avoid this combination. Use an alternative antifungal or select a different mineralocorticoid receptor antagonist strategy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.