Enzalutamide and Warfarin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Enzalutamide and Warfarin unless specifically directed by your doctor.
How Enzalutamide interacts with Warfarin
Enzalutamide strongly induces CYP3A4 and induces CYP2C9, increasing warfarin metabolism and potentially causing loss of anticoagulant control.
What you should do
Avoid the combination when possible. If warfarin must be used, monitor INR frequently during treatment and for several weeks after enzalutamide is stopped.
Key facts
Severity
Major — avoid combination
Mechanism
Enzalutamide strongly induces CYP3A4 and induces CYP2C9, increasing warfarin metabolism and potentially causing loss of ...
Action
Avoid the combination when possible. If warfarin must be used, monitor INR frequently during treatment and for several w...
Frequently asked questions
Can I take Enzalutamide and Warfarin together?
No — this combination should generally be avoided. Avoid the combination when possible. If warfarin must be used, monitor INR frequently during treatment and for several weeks after enzalutamide is stopped.
What is the severity of this interaction?
The interaction between Enzalutamide and Warfarin is classified as Major — avoid combination. Enzalutamide strongly induces CYP3A4 and induces CYP2C9, increasing warfarin metabolism and potentially causing loss of anticoagulant control.
What should I do if I'm prescribed both?
Avoid the combination when possible. If warfarin must be used, monitor INR frequently during treatment and for several weeks after enzalutamide is stopped. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.