Diazepam and Omeprazole: Drug Interaction Guide

Quick answer: Diazepam and Omeprazole have a minor interaction — typically manageable with awareness.

How Diazepam interacts with Omeprazole

Omeprazole inhibits CYP2C19-mediated diazepam metabolism, which may modestly prolong sedation and psychomotor impairment.

What you should do

Monitor for excessive sedation, particularly in older adults, and consider a benzodiazepine not dependent on CYP2C19 if symptoms occur.

Key facts

Severity

Minor — typically manageable

Mechanism

Omeprazole inhibits CYP2C19-mediated diazepam metabolism, which may modestly prolong sedation and psychomotor impairment...

Action

Monitor for excessive sedation, particularly in older adults, and consider a benzodiazepine not dependent on CYP2C19 if ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Diazepam and Omeprazole together?

Usually yes, with awareness. Monitor for excessive sedation, particularly in older adults, and consider a benzodiazepine not dependent on CYP2C19 if symptoms occur.

What is the severity of this interaction?

The interaction between Diazepam and Omeprazole is classified as Minor — typically manageable. Omeprazole inhibits CYP2C19-mediated diazepam metabolism, which may modestly prolong sedation and psychomotor impairment.

What should I do if I'm prescribed both?

Monitor for excessive sedation, particularly in older adults, and consider a benzodiazepine not dependent on CYP2C19 if symptoms occur. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: July 11, 2026 by iMedic Medical Editorial Team. Our editorial process.