Omeprazole and Vitamin B12: Drug Interaction Guide
Quick answer: Omeprazole and Vitamin B12 have a minor interaction — typically manageable with awareness.
How Omeprazole interacts with Vitamin B12
Long-term gastric acid suppression can reduce the release of protein-bound vitamin B12 from food and gradually impair its absorption.
What you should do
No immediate adjustment is usually required. Consider measuring vitamin B12 during prolonged therapy in patients with anaemia, neuropathy, malnutrition, or other risk factors.
Key facts
Severity
Minor — typically manageable
Mechanism
Long-term gastric acid suppression can reduce the release of protein-bound vitamin B12 from food and gradually impair it...
Action
No immediate adjustment is usually required. Consider measuring vitamin B12 during prolonged therapy in patients with an...
Frequently asked questions
Can I take Omeprazole and Vitamin B12 together?
Usually yes, with awareness. No immediate adjustment is usually required. Consider measuring vitamin B12 during prolonged therapy in patients with anaemia, neuropathy, malnutrition, or other risk factors.
What is the severity of this interaction?
The interaction between Omeprazole and Vitamin B12 is classified as Minor — typically manageable. Long-term gastric acid suppression can reduce the release of protein-bound vitamin B12 from food and gradually impair its absorption.
What should I do if I'm prescribed both?
No immediate adjustment is usually required. Consider measuring vitamin B12 during prolonged therapy in patients with anaemia, neuropathy, malnutrition, or other risk factors. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.