Dabigatran and Dronedarone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Dabigatran and Dronedarone unless specifically directed by your doctor.
How Dabigatran interacts with Dronedarone
Dronedarone inhibits P-glycoprotein, increasing dabigatran plasma concentrations and bleeding risk, particularly in patients with renal impairment.
What you should do
Avoid in severe renal impairment (CrCl <30 mL/min). In moderate impairment, reduce dabigatran dose to 75 mg twice daily and monitor for bleeding.
Key facts
Severity
Major — avoid combination
Mechanism
Dronedarone inhibits P-glycoprotein, increasing dabigatran plasma concentrations and bleeding risk, particularly in pati...
Action
Avoid in severe renal impairment (CrCl <30 mL/min). In moderate impairment, reduce dabigatran dose to 75 mg twice daily ...
Frequently asked questions
Can I take Dabigatran and Dronedarone together?
No — this combination should generally be avoided. Avoid in severe renal impairment (CrCl <30 mL/min). In moderate impairment, reduce dabigatran dose to 75 mg twice daily and monitor for bleeding.
What is the severity of this interaction?
The interaction between Dabigatran and Dronedarone is classified as Major — avoid combination. Dronedarone inhibits P-glycoprotein, increasing dabigatran plasma concentrations and bleeding risk, particularly in patients with renal impairment.
What should I do if I'm prescribed both?
Avoid in severe renal impairment (CrCl <30 mL/min). In moderate impairment, reduce dabigatran dose to 75 mg twice daily and monitor for bleeding. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.