Dabigatran and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Dabigatran and Rifampicin unless specifically directed by your doctor.
How Dabigatran interacts with Rifampicin
Rifampicin strongly induces intestinal P-glycoprotein, substantially reducing dabigatran absorption and anticoagulant exposure.
What you should do
Avoid coadministration because anticoagulant efficacy may be lost. Choose an alternative antimicrobial or anticoagulation strategy.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin strongly induces intestinal P-glycoprotein, substantially reducing dabigatran absorption and anticoagulant ex...
Action
Avoid coadministration because anticoagulant efficacy may be lost. Choose an alternative antimicrobial or anticoagulatio...
Frequently asked questions
Can I take Dabigatran and Rifampicin together?
No — this combination should generally be avoided. Avoid coadministration because anticoagulant efficacy may be lost. Choose an alternative antimicrobial or anticoagulation strategy.
What is the severity of this interaction?
The interaction between Dabigatran and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces intestinal P-glycoprotein, substantially reducing dabigatran absorption and anticoagulant exposure.
What should I do if I'm prescribed both?
Avoid coadministration because anticoagulant efficacy may be lost. Choose an alternative antimicrobial or anticoagulation strategy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.