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Clopidogrel and Omeprazole: Drug Interaction Guide

Quick answer: This combination requires caution. Clopidogrel and Omeprazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Clopidogrel interacts with Omeprazole

Omeprazole inhibits CYP2C19, reducing conversion of clopidogrel to its active metabolite.

What you should do

Use pantoprazole or rabeprazole as alternative PPIs; or use H2 blocker like famotidine.

Key facts

Severity

Moderate — caution required

Mechanism

Omeprazole inhibits CYP2C19, reducing conversion of clopidogrel to its active metabolite.

Action

Use pantoprazole or rabeprazole as alternative PPIs; or use H2 blocker like famotidine.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Clopidogrel and Omeprazole together?

With caution. Use pantoprazole or rabeprazole as alternative PPIs; or use H2 blocker like famotidine.

What is the severity of this interaction?

The interaction between Clopidogrel and Omeprazole is classified as Moderate — caution required. Omeprazole inhibits CYP2C19, reducing conversion of clopidogrel to its active metabolite.

What should I do if I'm prescribed both?

Use pantoprazole or rabeprazole as alternative PPIs; or use H2 blocker like famotidine. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.