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Clarithromycin and Simvastatin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Clarithromycin and Simvastatin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Clarithromycin interacts with Simvastatin

Clarithromycin is a strong CYP3A4 inhibitor that increases simvastatin plasma concentrations, raising risk of myopathy and rhabdomyolysis.

What you should do

Discontinue simvastatin during clarithromycin course or switch to a non-CYP3A4-dependent statin (pravastatin, rosuvastatin).

Key facts

Severity

Major — avoid combination

Mechanism

Clarithromycin is a strong CYP3A4 inhibitor that increases simvastatin plasma concentrations, raising risk of myopathy a...

Action

Discontinue simvastatin during clarithromycin course or switch to a non-CYP3A4-dependent statin (pravastatin, rosuvastat...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Clarithromycin and Simvastatin together?

No — this combination should generally be avoided. Discontinue simvastatin during clarithromycin course or switch to a non-CYP3A4-dependent statin (pravastatin, rosuvastatin).

What is the severity of this interaction?

The interaction between Clarithromycin and Simvastatin is classified as Major — avoid combination. Clarithromycin is a strong CYP3A4 inhibitor that increases simvastatin plasma concentrations, raising risk of myopathy and rhabdomyolysis.

What should I do if I'm prescribed both?

Discontinue simvastatin during clarithromycin course or switch to a non-CYP3A4-dependent statin (pravastatin, rosuvastatin). Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.