Simvastatin and Verapamil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Simvastatin and Verapamil unless specifically directed by your doctor.
How Simvastatin interacts with Verapamil
Verapamil inhibits CYP3A4 metabolism of simvastatin, raising plasma levels and the risk of myopathy and rhabdomyolysis, especially at higher statin doses.
What you should do
Limit simvastatin dose to 10 mg daily with verapamil per FDA labeling, or switch to pravastatin/rosuvastatin which avoid CYP3A4 metabolism.
Key facts
Severity
Major — avoid combination
Mechanism
Verapamil inhibits CYP3A4 metabolism of simvastatin, raising plasma levels and the risk of myopathy and rhabdomyolysis, ...
Action
Limit simvastatin dose to 10 mg daily with verapamil per FDA labeling, or switch to pravastatin/rosuvastatin which avoid...
Frequently asked questions
Can I take Simvastatin and Verapamil together?
No — this combination should generally be avoided. Limit simvastatin dose to 10 mg daily with verapamil per FDA labeling, or switch to pravastatin/rosuvastatin which avoid CYP3A4 metabolism.
What is the severity of this interaction?
The interaction between Simvastatin and Verapamil is classified as Major — avoid combination. Verapamil inhibits CYP3A4 metabolism of simvastatin, raising plasma levels and the risk of myopathy and rhabdomyolysis, especially at higher statin doses.
What should I do if I'm prescribed both?
Limit simvastatin dose to 10 mg daily with verapamil per FDA labeling, or switch to pravastatin/rosuvastatin which avoid CYP3A4 metabolism. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.